摘要
目的:研究了醋氯芬酸(Aceclofenac,AC)在纳米二氧化钛(nano-TiO2)与离子液体1-苄基-3-甲基咪唑六氟磷酸盐([BnMIM]PF6)复合修饰碳糊电极(nano-TiO2-[BnMIM]PF6/CPE)上的电化学行为和电化学动力学性质,建立了AC电化学定量测定方法。方法:循环伏安法(CV),计时电流法(CA),计时库仑法(CC),方波伏安法(SWV)以及电化学交流阻抗法(EIS)。结果:在nano-TiO2-[BnMIM]PF6/CPE上AC发生了受扩散控制的不可逆电化学氧化过程。测得AC在nano-TiO2-[BnMIM]PF6/CPE上的电极反应过程动力学参数。用SWV法测得AC氧化峰电流与其浓度在5.0×10-5～1.0×10-3mol·L-1呈线性关系,检测限(S/N=3)为1.20×10-7mol·L-1。采用本方法对市售醋氯芬酸片进行了电化学定量测定,RSD在1.9%～3.0%之间,加标回收率在98.6%～103.7%之间。结论:nano-TiO2-[BnMIM]PF6/CPE对AC电化学氧化具有良好的催化作用,该方法可用于市售醋氯芬酸含量的电化学定量测定。
Objectlve：Studied the electrochemical behaviors and electrochemical kinetic of Aceclofenac （AC） at nano - TiO2 and 1 - Benzyl - 3 - Methylimidazole hexafluorophosphate （ [ BnMIM ] PF6 ） modified carbon paste electrode （CPE）. At the same time, one electrochemical quantitative determination had been established. Methods： Cyclic Vohammetry （ CV）, Chronocoulometry （ CC ）, Chronoamperometry （ CA）, Electrochemical Impedance Spectrum （EIS） and Square Wave Voltammetry （SWV）. Results：Electrochemical experimental results show that AC electrochemical behavior in 0. 10 mol L-1 PBS exhibits an irreversible electrochemical redox process at nano- TiO2 - [ BnMIM ] PF6/ CPE. The electrochemical kinetics of Aeeelofenac （ AC ） at nano - TiO2 - [ BnMIM ] PF6/ CPE were measured. The oxidation peak current of AC versus its concentration have a good linear relationship in the concentration range of 5.0 ×10 -5 _ 1.0 × 10 -3 mol L-1 and the detection limit of 1.20 × 10 -7 mol L-1 by Square wave vohammetry （SWV） response. The quantitative determination of Aceelofenac （AC） content was investigated,the relative standard deviation is between 1.9% -3.0% and the recoverage is in the range of 98.56% - 103.7%. Conclusion：The experimental result indicated that nano - TiO2 - [ BnMIM ] PF6/CPE could catalyze the oxidation of AC well. Furthermore, this method can be applied in the test of Aceclofenac content with simple manipulation.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2012年第2期365-369,共5页
Chinese Journal of Pharmaceutical Analysis
