摘要
目的探讨新疆地区维吾尔族与汉族乙型肝炎病毒耐药基因型分布及耐药变异情况。方法采用基因芯片对来自维族、汉族人群乙型肝炎病毒核酸阳性的927份标本进行与乙型肝炎病毒耐药相关的rtL180M、rtM204I/V、rtA181T/V和rtN236T的耐药突变和基因型分析。结果维吾尔族与汉族的乙型肝炎病毒耐药突变率分别为53.26%和59.28%,差异无统计学意义;在4个耐药变异位点中,rtL180M、rtM204I/V、rtN236T3个位点的突变在两个民族之间差异无统计学意义;rtA181T/V在两个民族中的突变率分别为13.04%和31.74%,差异有统计学意义(χ2=13.8204,P<0.05)。结论维吾尔族与汉族的乙型肝炎病毒耐药突变不存在差异,4个突变位点的6种突变中,只有rtA181T/V在两个民族之间有差异,且维吾尔族低于汉族,rtL180M、rtM204I/V和rtN236仍是维吾尔族乙型肝炎病毒耐药的常见变异。
OBJECTIVE To analyze the distribution and mutation of resistant genotype of Hepatitis B virus in Uyghur and Han population in Xinjiang area.METHODS A total of 927 serum samples were collected from Uyghur and Chinese CHB patients with HBV DNA positive and resistance mutation and genotype analysis of rtL180M,rtM204I,rtM204V,rtA181T,rtA181V and rtN236T were done in all the samples by gene chips.RESULTS The mutation rate of HBV resistance in Uyghur and Chinese were 53.26% and 59.28%,the difference was not statistically significant（χ2 =1.2389,P〉0.05）;In the four mutant resistant sites,the differences between the two nations were not statistically significant in rtL180M,rtM204I/V and rtN236T mutations（P〈0.05）;The rate of rtA181T/V mutations in Uyghur and Chinese were 13.04% and 31.74%,and the difference was statistically significant（χ2=13.8204,P〈0.05）.CONCLUSION There is no difference between Uyghur and Chinese in hepatitis B virus resistance mutation.In the 6 kinds of mutations,only rtA181T/V is different between the two populations,and Uyghur is lower than Chinese.The rtL180M,rtM204I/V and rtN236 are still the common HBV resistance mutations in Uyghur.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第4期688-690,共3页
Chinese Journal of Nosocomiology
