摘要
目的探讨氟比洛芬酯（凯芬）在胸肌后假体隆乳术患者的术后镇痛效果。方法将120例胸肌后假体隆乳术患者随机分为4组（n=30）：A组（术前静注凯芬1mg／kg），B组（术后静注凯芬1mg／kg），C组（术前、术后分别静注凯芬1mg／kg），D组（空白对照）。分别记录各组患者术毕清醒拔管后即刻、2h,4h、12h的VAS（视觉模拟量表）评分。结果术后4h内A、c组VAS评分显著低于B组（P〈0．05），A组与c组VAS评分差异无统计学意义（P〉0．05）；术后12h内c组VAS评分显著低于A、B两组（P〈0．05）；术后12h内A、B、c3组VAS评分均显著低于D组（P〈0．05）；术后12h内各组恶心呕吐等不良反应发生率的差异无统计学意义（P〉0．05）。结论凯芬的超前镇痛效果确切，而术前、术后分别静注凯芬在术后12h内的镇痛效果优于术前单次给药，且未见明显恶心、呕吐等不良反应。
Objective To investigate the analgesic effect of flurbiprofen on postoperative pain after sub- muscular breast augmentation. Methods Totally 120 patients with submuscular breast augmentation in this study were divided into 4 groups randomly （ n = 30 ） ： Group A （ flurbiprofen 1 mg/Kg iv pre-operation）, Group B （flnrbiprofen 1 mg/kg iv post-operation）, Group C （flurbiprofen 1 mg/kg iv pre-operation and post- operation respectively） and Group D （sham control）. Visual analogue scales （VAS） were evaluated instantly, 2 h, 4 h and 12 h after extubation. Results In 4 hours postoperatively, VAS in Group A and Group C were both significantly lower than that in Group B （ P 〈 0.05 ）, and there was no significant difference in VAS between Group A and Group C （ P〉 0.05 ） ; In 12 hours postoperatively, VAS in Group C was significantly lower than that in Group A and Group B （P〈0.05） ; In 12 hours postoperatively, VAS in Group A, B and C was significantly lower than that in Group D （ P 〈 0.05） ; In 12 hours postoperatively, adverse effects such as nausea ~nd vomit seldomly happened in the cases in all the four groups. Conclusion Preoperative flurbiprofen can definitely pro- vide better analgesic effect. While a combination of preoperative and postoperative flurbiprofen would be a supe- rior method for 12 hours＇ analgesic effect, without obvious adverse effects like nausea or vomit at the same time.
出处
《中国美容整形外科杂志》
CAS
2012年第2期98-100,共3页
Chinese Journal of Aesthetic and Plastic Surgery
关键词
氟比洛芬酯
术后镇痛
隆乳术
Flurbiprofen
Postoperative analgesia
Breast augmentation
