摘要
目的:探讨心肌梗死后甲状腺素水平与心肌梗死预后的关系。方法:测定501例心肌梗死患者甲状腺素水平,并根据游离T3(FT3)水平分为低FT3组和正常FT3组,在心肌梗死1年后随访其死亡率及主要心血管事件发生率;随机选取部分患者1年后进行甲状腺素水平随访。结果:所有患者中171例FT3水平低于正常,所占比例为34.1%。随访期间,33例患者死亡,死亡率为6.6%,Kaplan-Meyer曲线示正常FT3组1年生存率明显高于低FT3组(97.3%∶86.0%,P<0.001);正常FT3组无心血管事件发生率明显高于低FT3组(54.5%∶33.3%,P<0.001)。对部分患者甲状腺素水平随访发现,1年后低FT3组FT3水平较心肌梗死入院时更低[(2.74±0.63)pmol/L∶(3.08±0.32)pmol/L,P<0.05],而在正常FT3组FT3水平无明显改变[(4.18±0.57)pmol/L∶(4.26±0.55)pmol/L,P>0.05]。结论:心肌梗死后低FT3是心肌梗死不良预后的预测指标,同时低FT3状态可能在心肌梗死后持续存在。
Objective：To investigate the relationship between thyroid hormone and prognosis of acute myocardial infarction（AMI）. Method：Five hundred and one patients with AMI were divided into two groups： normal free T3（FT3） group and low FT3 group according to the FT3 level at admission.The patients were followed up for 1 year for the mortality from any cause and major cardiac events.We detected the FT3 level in some of them. Result：A total 171 patients（34.1%） was in low level of FT3.During follow-up,33 patients（6.6%） died.Kaplan-Meyer survival curves showed that there was an overall survival rate of 86.0% and 97.3% for those with low FT3 and normal FT3,P0.001.The rates for NO MACE were 33.3% or 54.5% for patients with or without low FT3,P0.001.There was a significantly decrease in FT3 level followed up 1 year compared to admission in low FT3 group（[2.74±0.63]pmol/L∶[3.08±0.32]pmol/L,P0.05）,but not in normal FT3 group（[4.18±0.57]pmol/L∶[4.26±0.55]pmol/L,P0.05）. Conclusion：The low FT3 level is a strong predictor for the poor prognosis of AMI.Meanwhile,the low FT3 occurred at AMI would be persistent after AMI.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第2期124-128,共5页
Journal of Clinical Cardiology
关键词
急性心肌梗死
甲状腺素
低T3综合征
预后
acute myocardium infarction
thyroid hormone
low T3 syndrome
prognosis
