摘要
目的:分析去氨加压素治疗夜尿症的有效性及安全性。方法:检索MEDLINE、EMBASE、万方数据库,按Cochrane系统评价的方法评价纳入研究的质量,并提取资料,采用Revman软件进行统计分析。结果:共纳入5个随机、对照研究(RCT),包括619例患者,进行Meta分析。结果显示,去氨加压素能够有效减少夜尿频率及夜尿量,明显延长入睡后至第1次起床排尿的时间,改善患者生活质量,相对于安慰剂无明显不良反应。结论:去氨加压素治疗夜尿症有效、安全。
OBJECTIVE ： Randomized controlled trials （ To evaluate the efficacy and safety of desmopressin for nocturia. METHODS： RCT） on the efficacy and safety of desmopressin for nocturia were retrieved from Medline, Embase and Wanfang data bases and the quality of the included RCTs were evaluated using Cochrane systematic evaluation with the data analyzed statistically using Rev Man 5.0 software. RESULTS： Five RCTs involving 619 participants were included for the meta-analysis. Results of analysis showed that desmopressin could decrease the urinary frequency of nocturia and nocturnal urine volume, significantly prolong the time interval from going to sleep to first urination after falling asleep, improve patients＇ sleep quality yet without obvious adverse reactions as compared with placebo. CONCLUSION： Desmopressin is a safe and effective therapy for nocturia.
出处
《中国医院用药评价与分析》
2012年第1期6-9,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
