摘要
目的探讨Livin、Survivin和Caspase-3在星形细胞瘤中的表达。方法采用免疫组织化学法检测50例星形细胞瘤标本及10例正常脑组织中Livin、Survivin和Caspase-3的表达,分析Livin、Survivin的表达与Caspase-3表达的关系。结果 Caspase-3在正常脑组织中的阳性表达率显著高于在星形细胞瘤(P<0.05),且在Ⅰ～Ⅱ级星形细胞瘤中的阳性表达率高于Ⅲ～Ⅳ级(P<0.05)。Livin和Survivin在星形细胞瘤中的阳性表达率显著高于正常脑组织(P<0.05),且在Ⅲ～Ⅳ级星形细胞瘤中的阳性表达率明显高于Ⅰ～Ⅱ级(P<0.05)。星形细胞瘤中Livin和Survivin的表达与Caspase-3蛋白的表达均呈负相关(r分别为-0.520和-0.360,P<0.05)。结论 Livin、Survivin和Caspase-3的表达可能与星形细胞瘤的发生及发展有关。
Objective To explore the expression of Livin,Survivin and Caspase-3 in human brain astrocytoma.Methods The expressions of Livin,Survivin and Caspase-3 in fifty astrocytomas and ten normal brain tissues were detected with immunohistochemical method,and the relationships of Caspase-3 with Livin,Survivin were analyzed.Results The positive rate of Caspase-3 in normal tissue was significantly higher than that in human brain astrocytoma（P0.05）,it was higher in grade Ⅰ and Ⅱ than in grade Ⅲ and Ⅳ（P0.05）.The positive rates of Livin and Survivin in human brain astrocytoma were significantly higher than those in normal brain tissue（P0.05）,and they were higher in grade Ⅲ and Ⅳ than in grade Ⅰ and Ⅱ（P0.05）.The expressions of Livin and Survivin were negatively correlated with those of Caspase-3 in human brain astrocytoma（r=-0.520,r=-0.360,P0.05）.Conclusion Livin,Survivin and Caspase-3 may play an important role in incidence and development of human brain astrocytoma.
出处
《新乡医学院学报》
CAS
2012年第2期99-101,共3页
Journal of Xinxiang Medical University
