摘要
目的研究肝硬化伴消化道功能障碍患者酸化肠道治疗前、后的血氨水平变化,探讨肝硬化患者消化道状态与血氨水平的关系,寻找减少肠道氨吸收的有效方法,达到降低血氨的目的。方法测定195例肝硬化患者(包括单纯性肝硬化患者100例、肝硬化伴消化道出血患者52例、肝硬化伴便秘患者43例)、50例单纯性肠梗阻患者、113例单纯性消化道出血患者及80名正常对照者的空腹血氨水平。比较各组血氨水平,研究肝硬化伴消化道出血或(和)便秘患者酸化肠道治疗前、后的血氨水平变化。结果肝硬化伴消化道出血组血氨水平为(67.71±30.31)μmol/L,高于单纯性肝硬化组[(45.81±28.78)μmol/L]、单纯性消化道出血组[(24.85±10.79)μmol/L]和正常对照组[(22.42±7.93)μmol/L](P<0.05)。肝硬化伴便秘组血氨水平为(95.53±42.61)μmol/L,高于单纯性肝硬化组、肝硬化伴消化道出血组和单纯性肠梗阻组[(24.90±11.02)μmol/L](P<0.05)。单纯性肝硬化组血氨水平高于单纯性消化道出血、单纯性肠梗阻组及正常对照组(P<0.05);而单纯性消化道出血、单纯性肠梗阻组与正常对照组比较差异无统计学意义(P>0.05)。肝硬化伴消化道出血或(和)便秘组治疗前血氨水平为(83.28±37.93)μmol/L,明显高于经酸化肠道治疗后的血氨水平[(50.89±19.58)μmol/L](P<0.05)。结论肝硬化患者消化道状态与血氨水平关系密切;阻止消化道出血、酸化肠道及使用抗生素可抑制肠道中氨的产生和吸收,从而降低血氨水平,预防和治疗肝性脑病。
Objective To study the changes on plasma ammonia among cirrhosis patients who had gastrointestinal symptoms before and after acidification intestinal treatment,investigate the relationship of gastrointestinal state and plasma ammonia among cirrhosis patients,and find an effective method to reduce plasma ammonia.Methods The fast plasma ammonia levels were detected among 195 cirrhosis patients（including 100 patients with just cirrhosis,52 cirrhosis patients with gastrointestinal hemorrhage and 43 cirrhosis patients with constipation）,50 patients with just intestinal obstruction,113 patients with just gastrointestinal hemorrhage and 80 healthy subjects.The plasma ammonia levels were compared,and the changes on plasma ammonia levels before and after acidification intestinal treatment were analyzed in cirrhosis patients with gastrointestinal hemorrhage and（or） constipation.Results Plasma ammonia level among cirrhosis patients with gastrointestinal hemorrhage was（67.71±30.31） μmol/L,which was higher than those of patients with just cirrhosis [（45.81±28.78） μmol/L],patients with just gastrointestinal hemorrhage [（24.85±10.79） μmol/L] and the healthy controls [（22.42±7.93） μmol/L]（P〈0.05）.The plasma ammonia level of cirrhosis patients with constipation was（95.53±42.61） μmol/L,which was higher than those of patients with just cirrhosis,cirrhosis patients with gastrointestinal hemorrhage and patients with just intestinal obstruction [（24.90±11.02） μmol/L]（P〈0.05）.The plasma ammonia level of patients with just cirrhosis were higher than those of patients with just gastrointestinal hemorrhage,patients with just intestinal obstruction and healthy subjects（P〈0.05）,while the plasma ammonia levels among patients with just intestinal gastrointestinal hemorrhage,patients with just obstruction and the healthy subjects showed no significant difference（P〉0.05）.The plasma ammonia levels of cirrhosis patients with gastrointestinal hemorrhage and（or） constipation be
出处
《检验医学》
CAS
2012年第1期44-47,共4页
Laboratory Medicine
关键词
血氨
肝硬化
消化道出血
便秘
Plasma ammonia
Cirrhosis
Gastrointestinal hemorrhage
Constipation
