摘要
骨桥蛋白(Osteopontin,OPN)是一种磷酸化蛋白质,在人体组织中广泛分布,具有多种功能。OPN不与在组织发育过程,而且与许多疾病,如炎症、免疫反应、血管重建等有关。OPN与肿瘤转移的关系日益引起人们的关注,已被广泛公认为是肿瘤转移相关基因或转移基因。针对肿瘤转移基因OPN及其受体的干预,可能成为防治肿瘤转移的潜在靶点。同时,OPN也可能是肿瘤远处转移和预后的预测分子。本文就骨桥蛋白与恶性肿瘤侵袭转移之间的研究进展进行综述。
Osteopontin belongs to the family of phosphorylated protein.It distributed in various human tissues and was known to have multiple functions.OPN not only reacts during tissue development,but also related with many diseases,such as inflammation,immune response,and revascularization.Recently,much attention was paid to the role of OPN on tumor metastasis.It was generally accepted as a metastasis-related gene or a metastic gene.The intervention in the metastatic gene OPN or its receptors were considered as potent therapeutic targets for tumor metastasis.Meanwhile,OPN could serve as a predicter for distal metastasis as well as a prognosis factor for malignant tumors.Here we reviewed the up-to-date investigations on the role of OPN in malignant infiltration and metastasis.
出处
《现代肿瘤医学》
CAS
2012年第2期419-422,共4页
Journal of Modern Oncology
基金
辽宁省科学技术研究基金项目(编号:2010225015)
关键词
骨桥蛋白
恶性肿瘤
转移
侵袭
osteopontin
malignancies
metastasis
infiltration
