摘要
目的:考察5种胸外科术后常用静滴液的稳定性。滴液(1)内含氯化钾、硫酸镁、辅酶A、胰岛素、三磷酸腺苷、维生素B6、维生素C等7种药物,以10%葡萄糖注射液为溶媒;滴液(2)以滴液(1)为基础加入多巴胺、多巴酚丁胺;滴液(3)、(4)、(5)以滴液(2)为基础分别加入呋塞米;肝太乐、强力宁;呋塞米、肝太乐、强力宁。方法:采用褶合光谱法结合外观和pH值检查法并以差谱值予以定量表达。结果:5种滴液8h内外观均无变化;pH值均较稳定;4h差谱值分别为0.49%,1.40%,1.79%,1.31%,1.20%。结论:滴液(3)与滴液(5)的内在药物经过8h后有较明显的变化。
OBJECTIVE:To observe the chemical stability of five transfusion fluids used after surgical operation.METHODS:The convolution spectrometries of the five samples were determined in 4 and 8h,and the appearances were observed.The results were described quantitatively by subtract spectrometry value.RESULTS:There were no obvious change in the appearances and pH in 8h.The subtract spectrometry values after 4h were 0.49% , 1.40% , 1.79% , 1.31% and 1.20% ,respectively.CONCLUSIONS:Some obvious changes in the third and the fifth transfusion fluid were found from the subtract spectrometry,and attentions should be paid to it in clinic.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第2期75-77,共3页
Chinese Journal of Hospital Pharmacy
关键词
褶合光谱法
药物稳定性
葡萄糖注射液
convolution spectrometry
stability of drugs
10% glucose injection
