摘要
乳腺癌在女性癌症死亡中占有重要地位,侵袭转移是目前乳腺癌治疗的一大难点。近年来,多种miRNAs已被证明涉及乳腺癌的发生发展。其中miR-10b在转移性乳腺癌中高度表达,通过TwistmiR-10b-HOXD10-RhoC信号通路在乳腺癌的侵袭和远处转移中发挥重要作用,这使它成为针对乳腺癌转移治疗的新靶点。
Breast cancer occupies a dominant position in female cancer,and the invasion and metastasis of breast cancer has been a major difficulty to its treatment at present.In recent years,a variety of miRNAs are demonstrated to be involved in cancer initiation and progression.miR-10b,as a member of the miRNA family,which is over expressed in the metastatic breast cancer,plays an important role in the invasion and metastasis of breast cancer via Twist-miR-10b-HOXD10-RhoC signaling pathway.It can be exploited therapeutically for treating breast cancer metastasis.
出处
《海南医学》
CAS
2012年第3期112-114,共3页
Hainan Medical Journal
