摘要
收集早、中、晚期口腔黏膜下纤维性变(oral submucous fibrosis,OSF)组织各10例及正常的口腔颊黏膜组织5例,采用免疫组化SABC法对各种组织中的HGF及c-met的表达情况进行检测。结果显示在正常的口腔颊黏膜组织中HGF和c-met呈阳性表达,早、中、晚期OSF组织中表达明显降低(P<0.05)。说明HGF/c-met在OSF组织中表达受到抑制,促进了OSF的发病。
The immunohistochemical SABC method was used to detect the expression and distribution of HGF and c-met in 5 heathy controllers and 30 cases of oral submucous fibrosis（OSF）.The positive expression of HGF and c-met was found in normal oral mucosa and a significant decrease of the expression was observed in early,intermediate and advanced stages of OSF（P0.05）.Reduction of HGF and c-met expression may contribute to the pathogenesis of OSF.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2012年第1期110-113,共4页
Journal of Practical Stomatology
关键词
口腔黏膜下纤维化
肝细胞生长因子
肝细胞生长因子受体
免疫组织化学
Oral submucous fibrosis（OSF）
Hepatocyte growth factor（HGF）
Hepatocyte growth factor receptor
Immunohistochemistry
