摘要
目的观察经过2年自动调节压力持续正压通气（AUTO-CPAP）治疗中、重度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的患者体质量指数（BMI）的变化，停机后呼吸暂停低通气指数（AHI）、最低血氧饱和度（LSPO2）、微觉醒指数（MAI）、Ⅰ～Ⅱ期及Ⅲ～Ⅳ期睡眠时间占总睡眠时间百分比（Ⅰ～Ⅱ％，Ⅲ～Ⅳ％）的变化，探讨长期AUTO-CPAP呼吸机治疗对患者BMI的影响以及治疗后停机对患者的影响。方法选取42例中、重度OSAHS患者，经AUTO—CPAP治疗2年、治疗时间≥5h／d，治疗结束后对患者停机，并对患者行多导睡眠呼吸监测，观察治疗前后患者BMI、AHI、LSPO2、MAI、Ⅰ～Ⅱ％、Ⅲ～Ⅳ％的变化。结果长期AUTO—CPAP治疗前后患者BMI无明显变化（P〉0．05），当治疗停止时，AHI从（43．6±12，6）次／h减少到（36．7±11．2）次／h，减少了（6．8±3．2）次／h（P〈0．01），LSP02从（69．3±10．2）％上升到（76．4±8．1）％，升高了（7．1±2．6）％（P〈0．01），MAI从（38．1±12．2）次／h上升到（44．2±13．1）次／h，上升了（2．1±3．2）次／h（P〈0．01）。Ⅰ～Ⅱ％，Ⅲ～Ⅳ％无明显变化（P〉0．05）。结论长期AUTO—CPAP治疗OSAHS对患者BMI无明显影响；有利于降低患者原有AHI、提高LSPO2；停机后对患者的影响主要表现在MAI的增加，而与Ⅰ～Ⅱ％、Ⅲ～Ⅳ％无关。
Objective To observe the changement of body mass index （BMI）, apnea hypopnea index （AHI）, lowest pulse oxygen saturation （LSPO2）,micro-arousal index （MAD, percentage of sleep Ⅰ～Ⅱ stage time and Ⅲ～Ⅳ stage time in the total time （ Ⅰ～Ⅱ %, Ⅲ～Ⅳ） in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） who had been treated with auto-continuous positive airway pressure （AUTO-CPAP） for two years. Methods The 42 patients who were diagnosized OSAHS with polysomnography （PSG） had been treated with AUTO-CPAP for two years, and the treatment time was not less than 5 hours pre day. The second PSG was taken in this patients after a two-years treatment. To observe the changement of the BMI, AHI, LSPO2, MAI, Ⅰ～Ⅱ %, Ⅲ～Ⅳ from pre-treatment to post-treatment. Results The BMI showed no difference between pre-treatment and post treatment （ P 〈0.05）. When the treatment being quitted, AHIreduced （6.8±3.2） times/h from （43.6±12.6） times/h to （36.7±11.2） times/h （P 〈0.05）. And LSPO2 raised （7.14±2.6）% from （69.3± 10.2）% to （76.4±8.1）% （P 〈0.05）. The MAI raised （2.1±3.2） times/h from （38.1±12.2） times/h to （44.2±13.1） times/h （ P 〈0.05）. And Ⅰ～Ⅱ %, Ⅲ～Ⅳ% shows no difference between pre-treatment and post-treatment （ P 〉0.05）. Conclusions A long term treatment with AUTO-CPAP shows likely no influence to the BMI of the patients with OSHAS. A long term treatment with AUTO-CPAP is maybe benefit to the AHI and LSPO2. When the treatment being quitted, the influence to the patient not lies in Ⅰ～Ⅱ %, Ⅲ～Ⅳ% but in theMAI.
出处
《国际呼吸杂志》
2012年第3期201-203,共3页
International Journal of Respiration
