摘要
目的了解该院神经外科ICU感染的病原菌分布及耐药情况,指导临床合理使用抗菌剂。方法将该院神经外科ICU2009年1月至2010年12月送检的标本进行回顾性分析。结果分离出病原菌369株,其中G-杆菌占64%(236株),G+球菌占21%(77株),念珠菌属占10%(37株),其他占5%(19株)。分离出的前5位细菌依次为:肺炎克雷伯菌、铜绿假单胞菌、凝固酶阴性葡萄球菌、白假丝酵母菌、大肠埃希菌。G-杆菌对常用抗菌剂显示不同程度耐药,但亚胺培南、头孢哌酮/舒巴坦、头孢吡肟、阿米卡星、哌拉西林/他唑巴坦显示了良好的抗菌活性,尚未发现对万古霉素耐药的葡萄球菌。结论神经外科ICU感染的病原菌耐药率高,应加强耐药监测,合理使用抗菌剂。
Objective To investigate bacterial resistance of clinical isolates from neurosurgical intensive care unit and find out pathogen distribution.Methods 369 strains of bacteria were isolated from clinical samples between 2009 and 2010.Results The number of gram-negative were 236 strains（64%）,gram-positive bacteria were 77 strains（21%）,candida were 37 strains（10%）,other bacteria were 19（5%）.According to quantity order,the first was K.pneumoniae,then were P.aeruginosa,stapthyococcus,candida,E.coli.Gram-negative organisms were different resistant to common antibiotics;but,imipenem,cefoperzone/sulbactam,cefpriome,amikacin piperacillin/tazo-bactam,had powerful antibacterial activity,not found any stapthyococcus was resistant to vancomycin.Conclusion The drug-resistance of pathogens in neurosurgical intensive care unit is deteriorated.It is necessary to continuously monitor the drug-resistance of bacteria and rationally use antibiotics.
出处
《国际检验医学杂志》
CAS
2011年第20期2361-2363,共3页
International Journal of Laboratory Medicine
关键词
重症监护病房
抗药性
抗菌药
intensive care unit drug-resistance anti-bacterial agents
