摘要
【目的】研究胸腔内注入滑石粉浆的急性反应。【方法】50只新西兰雄性白兔胸腔内接受400mg/kg滑石粉后的6h、1、2、4和7d分成5组作实验观察,另10只作为对照组接受生理盐水。【结果】对照组1d内胸水基本吸收,实验组胸水渗出量在第4d达到高峰,第7d完全吸收。白细胞数明显升高,1d内以中性粒细胞占优势,此后则以淋巴细胞为主。LDH迅速增高,于第2天达高峰。胸膜粘连带在第6小时开始形成,第4天后明显增加。镜下胸膜炎症以第2天最严重,而纤维化则第7天最明显。【结论】滑石粉浆可引起急性胸膜炎症和纤维化,是安全、有效的硬化剂。注入后不必引流。
Objective To study the acute effects of talc instillation intrapleurally. Methods 50 New Zealand white male rabbits were divided into 5 groups according to the study period of 6 hours, 1,2,4 and 7 days after instillation. 10 rabbits received saline intrapleurally as control. Results The pleural fluid was almost absorbed in control on day 1, however, the exudative fluid reach its peak on day 4 and completely disappeared on day 7 after instillation in talc groups. WBC was obviously increase, neutrophils were prominent on day 1 and after then the lymphocytes dominated. The levels of LDH increased rapidly and reached its peak on day 2. The pleural adhesions formed at 6 hour and significantly increased after day 4. Pleural inflammation microscopically was the most obvious on day 2 and fibrosis on day 7. Conclusion Talc slurry induces acute pleural inflammation and is a safe, effective sclerosant. It seems not necessary to drain after instillation.
出处
《中山医科大学学报》
CSCD
2000年第1期21-23,26,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
