摘要
目的:探讨红花注射液对断指再植术后缺血再灌注损伤治疗的临床疗效。方法:2009年8月至2011年02月选取我院就诊患者中完全离断断指186病例200指,随机分为缺血再灌注损伤组、对照组,分别记录抗缺血在灌注损伤组和对照组血管痉挛、血管栓塞、指体坏死发生的例数。选取部分患者测定血清丙二醛(MDA)、超氧化物歧化酶(SOD)在灌注前后的变化,并进行统计学分析。结果:对照组断指存活率86%,抗缺血再灌注损伤组断指存活率95%。抗缺血再灌注损伤组与对照组断指再植术后血管痉挛、血管栓塞、断指坏死发生率差异具有显著性差异(P<0.05)。断指再指术后红花注射液能减少MDA的产生,提高SOD的活性,抗缺血再灌注损伤组再灌注后24h及1周的血液中MDA和SOD含量与对照组相比有显著性差异(P<0.05)。结论:红花注射液能减轻断指再指术后缺血再灌注损伤,减少术后并发症的发生,提高了断指再植的成功率,疗效确切,无明显不良反应。
Objective： The purpose of the study was to investigate the effect of the Safflower on ischemia-reperfusion injury in the replantation of fingers.Methods： From August 2009 to February 2011 a total 0f 186 cases with 200 fingers were selected.All the patients were divided into 2 groups randomly,anti-ischemia-reperfusion injury group and control group.The indexes of vasospasm,vascular em-bolism and finger necrosis were a was used and the results were observed after the replantation.The level of malondialdehyde（MDA） and superoxide dismutase（SOD） in the blood serum were tested in partial samples.The resuits were statistically analyzed,with a Pvalue less than 0.05 indicating significant difference.Resuits： Livability of the replanted fingers was 86% in the control group,95% anti-ischemi-a-reperfusion injury group.The frequency of the two groups had significant differences in the vasospasm,vascular embolism and finger necrosis（P0.05）.Safflower can reduce the productivity of MDA and promote the activities of SOD.There were significant differences of the MDA and SOD in the two groups（P0.05）.Conclusion： Based on the results of the study,Safflower can reduce the ischemia-reperfu-sion injury after replantation of the fingers and the complication,so as to increase the survival rate,and get no untoward effect.
出处
《现代生物医学进展》
CAS
2011年第24期4877-4879,共3页
Progress in Modern Biomedicine
基金
南京医科大学科技发展基金项目(09NJMUM073)
南京市医学科技发展项目(QYK10134)
关键词
红花注射液
缺血再灌注损伤
断指再指
自由基
Safflower
Ischemia-reperfusion injury
Isolated limbs replantation
Free radical svavenger
