摘要
目的研究热熔挤出技术制备的固体分散体提高安宫牛黄固体分散体中黄芩苷的溶出速率。方法分别以泊洛沙姆-188、聚乙二醇6000为亲水性载体,与处方中栀子、黄芩、黄连、郁金提取物粉末按1∶4比例混合均匀,采用热熔挤出技术制备固体分散体。比较两者差示扫描量热图谱和累积溶出曲线。结果溶出结果显示,两种固体分散体中难溶性成分黄芩苷20 min累积溶出度均达到90%以上,溶出速率显著优于物理混合物。结论 热熔挤出技术制备的固体分散体中溶解度差、溶出速率较慢成分累积溶出速率显著提高。
AIM To study the hot melt extrusion to improve the baicalin dissolution in Angong Niuhuang Dispersion.METHODS Poloxamer-188 and polyethylene glycol 6000 were adopted as hydrophilic carrier.Ethanolic extract,from Gardeniae Fructus,Scutellariae Radix,Coptidis Rhizoma and Curcumae Radix,and carriers mingled with each other in the proportion of 1∶ 4 to prepare the physical mixture as compared with the mixture made in hot melt extrusion,and made the comparison between them in the differential scanning calorimetry spectrum and the cumulative dissolution curves.RESULTS The dissolution results showed that the 20 min cumulative dissolution of baicalin in both the two solid dispersion reached 90%,but hot melt extrusion was significantly better than the physical mixture.CONCLUSION Hot melt extrusion can improve the dissolution of insoluble components like baicalin in Angong Niuhuang Dispersion.
出处
《中成药》
CAS
CSCD
北大核心
2012年第1期38-41,共4页
Chinese Traditional Patent Medicine
基金
陕西省中医管理局中医药科研课题(ZY29)
