期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TBX1基因与心脏圆锥动脉干畸形的相关研究 被引量：4

Relevant Research on TBX1 Gene with Human Conotruncal Defects
下载PDF
导出
摘要 心脏圆锥动脉干畸形是婴幼儿期常见的青紫型先天性心脏病,主要由于胚胎期心脏发育异常所致。现综述TBX1基因在心脏发育过程中的作用以及可能的作用机制等国内外近几年的研究进展,旨在揭示TBX1基因与心脏圆锥动脉干畸形的关联。 Conotruncal defects is a cyanotic congenital heart disease commonly seen in infants, mainly resulted from the abnormal development of the cardiovascular system in embryos. This review focused on recent advances in the effects and possible mechanisms of the TBX1 gene in cardiac development, aiming to discuss the relationship between the TBX1 gene and contruncal defects.
作者 韩秀敏 鲍卫东
机构地区 沈阳军区总医院先心病内科 辽宁省军区沈阳第三干休所
出处 《心血管病学进展》 CAS 2012年第1期110-113,共4页 Advances in Cardiovascular Diseases
关键词 TBX1基因 圆锥动脉干畸形 心脏发育 TBX1 gene contruncal defects cardiac development
分类号 R541.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献1

二级参考文献24

  • 1Jerome LA,Papaioannou VE.DiGeorge syndrome phenotype in mice mutant for the T-box gene,Tbxl.Nat Genet 2001; 27:286-291. 被引量：1
  • 2Lindsay EA,Vitelli F,Su H,Morishima M,Huynh T,Pramparo T,et al.Tbxl haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.Nature 2001;410:97-101. 被引量：1
  • 3Merscher S,Funke B,Epstein JA,Heyer J,Puech A,Lum M,et al.Tbxl is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.Cell 2001; 104:619-629. 被引量：1
  • 4Taddei I,Morishima M,Huynh T,Lindsay EA.Genetic factors are major determinants of phenotypic variability in a mouse model of the DiGeorge/del22qll syndromes.Proc Nad Acad Sci USA 2001;98:11428-11431. 被引量：1
  • 5Piotrowski T,Ann DG Schilling TF,Nair S,Ruvinsky I,Geisler R,et al.The zebrafish van gogh mutation disrupts tbxl,which is involved in the DiGeorge deletion syndrome in humans.Development 2003; 130:5043-5052. 被引量：1
  • 6Vitelli F,Huynh T,Baldini A.Gain of function of Tbxl affects pharyngeal and heart development in the mouse.Genesis 2009; 47:188-195. 被引量：1
  • 7Yagi H,Furutani Y,Hamada H,Sasaki T,Asakawa S,Minoshima S,et al.Role of TBX1 in human del22qll.2 syndrome.Lancet 2003; 362:1366-1373. 被引量：1
  • 8Nichols CA,Creazzo TL.L-type Ca2+ channel function in the avian embryonic heart after cardiac neural crest ablation.Am J Physiol Heart Circ Physiol 2005; 288:H1173-H1178. 被引量：1
  • 9Hu N,Sedmera D,Yost HJ,Clark EB.Structure and function of the developing zebrafish heart.Anat Rec 2000; 260:148-157. 被引量：1
  • 10Fishman MC,Chien KR.Fashioning the vertebrate heart:earliest embryonic decisions.Development 1997; 124:2099-2117. 被引量：1

共引文献4

同被引文献76

  • 1钟晓红,李胜利,陈琮瑛,刘菊玲,毕静茹,文华轩.法洛四联症的胎儿期超声心动图特征[J].中国超声医学杂志,2005,21(7):552-554. 被引量：44
  • 2桂永浩.先天性心脏病产前诊断及其临床意义[J].中国小儿急救医学,2006,13(5):399-401. 被引量：24
  • 3Alexandrovich A,Amo M,Patient RK,et al. Wnt2 is a direct downstream target of GAT A6 during early cardiogenesis. Mech Dev, 2006 ,123( 4) :297-311. 被引量：1
  • 4Lin X, Huo Z, Liu X, et al. A novel GAT A6 mutation in patients with tetralogy of Fallot or atrial septal defect.J Hum Genet,2010 ,55 (10) :662-667. 被引量：1
  • 5Suzuki YJ. Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Cell Signal,2011 ,23(7) :1094-1099. 被引量：1
  • 6Pikkarainen S, Tokola H, Kerkela R, et al. GAT A transcription factors in the developing and adult heart. Cardiovasc Res ,2004,63 (2) : 196-207. 被引量：1
  • 7Brewer A, PizzeyJ. GAT A factors in vertebrate heart development and disease. Expert Rev Mol Med,2006 ,8(22) :1-20. 被引量：1
  • 8Peterkin T ,Gibson A,Loose M,et al. The roles of GATA4,-5 and- 6 in vertebrate heart development. Semin Cell Dev Bioi, 2005,16 (1) :83-94. 被引量：1
  • 9Kodo K, Nishizawa T, Furutani M, et al. GAT A6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. Proc Natl Acad Sci U S A,2009 ,106(33) : 13933-13938. 被引量：1
  • 10Keyte A, Hutson MR. The neural crest in cardiac congenital anomalies. Differentiation ,2012 ,84(1) :2540. 被引量：1

引证文献4

二级引证文献23

心血管病学进展
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部