摘要
胰高血糖素样肽-1（GLP-1）是由肠道内分泌L细胞分泌的一种重要的肠促胰岛素，具有促进胰岛素分泌、增加葡萄糖利用、降低血糖等生物学作用。研究显示，GLP-1具有明显的心脏保护作用，主要通过抑制心肌细胞凋亡、改善心肌收缩力、促进心肌葡萄糖的利用等直接或间接发挥其心脏保护作用，并逐渐应用于临床。进一步深入探讨GLP-1的心脏保护作用机制有助于临床上为心血管疾病患者提供新的治疗思路。
Glucagon-like peptide-1 （GLP-1） is an important incretin secreted by endocrine L cells in intestinal tract, with biological effects on promoting insulin secretion, increasing glucose uptake and reducing serum glucose. Studies have shown that GLP-1 has an obvious cardioprotective effect mainly achieved by inhibiting myocardial cells apoptosis, improving myocardial contractility, and increasing myocardial glucose uptake, which can directly or indirectly protect the heart, and has been used in patients. Further investigation of the mechanism of cardioprotective effect of GLP-1 may provide new clues for treating patients with cardiovascular diseases.
出处
《国际内分泌代谢杂志》
北大核心
2012年第1期35-37,共3页
International Journal of Endocrinology and Metabolism
