期刊文献+

RNA干扰逆转肿瘤细胞的多药耐药性

下载PDF
导出
摘要 化疗是目前肿瘤治疗的主要措施,而肿瘤多药耐药性(multiresistance,MDR)的产生是肿瘤化疗失败的主要原因。肿瘤MDR机制非常复杂,逆转肿瘤MDR的方法也多种多样,但目前临床上尚未有从根本上完全逆转MDR的理想药物。RNA干扰是最近几年研究逆转MDR的热点,为临床上研制高效、低毒、特异性强的逆转剂提供了前景。
作者 王军 李凯
出处 《内蒙古医学杂志》 2011年第10期1199-1202,共4页 Inner Mongolia Medical Journal
  • 相关文献

参考文献4

二级参考文献28

  • 1JunGUO,Yu-caiFU,CarlosRBECERRA.Dissecting role of regulatory factors in NF-κB pathway with siRNA[J].Acta Pharmacologica Sinica,2005,26(7):780-788. 被引量:6
  • 2Cole SPC, Bhardwa JG, Gerlach JH, et al. Overexpression of transporter gene in a mulfidrug-resistant human lung cancer cell line.Science, 1992, 258 : 1650-1654. 被引量:1
  • 3Bradshaw DM, Arceci BJ. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol, 1998,16 : 3674 -3690. 被引量:1
  • 4Breunlnger LM, Paul S, Gaughan K, et al. Expression of multidrug resistance-associated protein in NIH/3T3 cells coders muhidrug resistance associated with increased drug etllux and altered intracellular drug distribution. Cancer Res, 1995, 55:5342-5347. 被引量:1
  • 5Hipfner DR, Deeley RG, Coloe SP. Structural, mechanistic and clinical aspects of MRPI. Biochim Biophys Acta, 1999, 1461:359-376. 被引量:1
  • 6Sczakiel G. The design of antisense RNA. Antisense Nucleic Acid Drug Dev, 1997, 7:439-444. 被引量:1
  • 7Richert ND, Aldwin L, Nitesci D, et al. Stability and covalent modification of P-glycoprotein in multidrug resistance KB cells.Biochemistry, 1988, 27:760. 被引量:1
  • 8Christiane N, Axel P, Alexandra S. Modulation of classical multidrug resistance phenotype by RNA interference [ J ]. FEBS Letters,2003,545 (2) :145 - 150. 被引量:1
  • 9Pakunlu RI,Wang Y,Tsao W,et al. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense : novel multicomponent delivery system [ J ]. Cancer Research, 2004, 64 (17) :6214 - 6223. 被引量:1
  • 10De Pauw R, van Meerbeeck JP. Neoadjuvant chemotherapy in the treatment of non small-cell lung cancer [ J ]. Curt Opin Oncol, 2007, 19(2) :92 -97. 被引量:1

共引文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部