摘要
目的:分析探讨各生化指标动态监测对妊娠期肝内胆汁淤积症早期预警的临床意义。方法:选取患妊娠期肝内胆汁淤积症孕妇和产科检查正常孕妇各50例进行生化指标动态监测。结果:ALT、AST、ALP、GGT、BIL等指标在早、中、晚各孕期两组间差别均有统计学意义(P<0.05),而TP和ALB整个孕周两组间差别无统计学意义(P>0.05)。ALT、AST、T-BIL、D-BIL在正常孕妇组早、中、晚孕期无差别(P>0.05),但在妊娠期肝内胆汁淤积症孕妇组差别有统计学意义(P<0.05)。通过ROC曲线分析,D-BIL/T-BIL在孕中期的诊断敏感性已经达到53%。结论:血清BIL水平对妊娠期肝内胆汁淤积症诊断意义不大,但D-BIL/T-BIL比值>0.35是妊娠期肝内胆汁淤积症重要特征之一,可以作为临床早期预警指标。
Objective：To analyze the clinical value of various biochemical indexes dynamic monitoring on intrahepatic cholestasis of pregnancy pre-warning.Methods： 50 pregnant women with intrahepatic cholestasis of pregnancy and 50 pregnant women with obstetrics checking normal were enrolled.Various biochemical indexes of all eligible patients were conducted dynamic monitoring.Results： During the whole gestational weeks,the biochemical indexes such as ALT,AST,ALP,GGT,BIL but ALB and TP showed significant differences both on women with intrahepatic cholestasis of pregnancy and women with obstetrics checking normal.The biochemical indexes such as ALT,AST,T-BIL,D-BIL showed significant differences during the whole gestational weeks on women with intrahepatic cholestasis of pregnancy but not on women with obstetrics checking normal.The ROC curves analysis showed diagnostic sensitivity of D-BIL/T-BIL in mid-pregnancy had reached 53%.Conclusion： Serum BIL level was not significant to diagnosis of intrahepatic cholestasis of pregnancy,but the ratio of D-BIL/T-BIL above 0.35 was one of the important characteristics of intrahepatic cholestasis of pregnancy,which can be taken as the early warning index in clinic.
出处
《中国卫生检验杂志》
CAS
2011年第12期2917-2919,共3页
Chinese Journal of Health Laboratory Technology
关键词
妊娠期肝内胆汁淤积症
动态监测
预警
Intrahepatic Cholestasis of Pregnancy
Dynamic monitoring
Pre-warning
