摘要
目的 研究一种具有高度敏感性和特异性的血清标记物,能够早期诊断前列腺癌。方法 收集200例病例分为3组,第1组:100例经确诊为前列腺癌;第2组:50例经确诊为前列腺增生与肥大;第3组:50例正常人为阴性对照。然后,分别对它们采取血液进行前列腺特异性抗原和酸性磷酸酶水平的定量检测,研究其阳性率、敏感性和特异性。结果 阳性率:TPSA为97%,ACP为12%;敏感性:TPSA为100%,ACP为10%;特异性:TPSA为97%,ACP为12%。结论 TPSA阳性结果可以诊断为前列腺癌或前列腺增生与肥大,TPSA的阴性结果可排除前列腺癌。因此,当前列腺发生癌变时,TPSA可作为一种高度敏感性和特异性的血液标记物,TPSA可以早期诊断前列腺癌和前列腺增生与肥大。
Objective To investigate a highly sensitive and specific blood marker,it can earlier eamine and diagnose a patient with prostate cancer.Methods 200 case were divided into three groups.The first group,100 case were diagnosed into prostate cancer.The second group,50 case were diagnosed into prostate hyperplasia or hypertrophy.And the third group,50 case were negative comparison.Respectively took its blood into be measured the TPSA and ACP levels,studying its positive rate,sensitivity and specificity.Results TPSA positive rate was 97%,sensitivity was 100%,specificity was 97%;ACP positive rate was 12%,sensitiveity was 10%,specificity was 12%.Conclusion TPSA positive result can diagnose into prostate cancer,prostate hyperplasia or hypertrophy.TPSA negative result can exclude prostate cancer.Therefore,TPSA is the highly sensitive and specific blood marker as prostate arises cancer.It can early diagnose prostate cancer,prostate hyperplasia or hypertrophy.
出处
《中国医药科学》
2012年第1期133-134,共2页
China Medicine And Pharmacy
关键词
前列腺特异性抗原
前列癌
前列腺增生
前列腺肥大
酸性磷酸酶
Prostate specific antigen； Prostate cancer； Prostate hyperplasia； Prostate hypertrophy； Acid phosphatase；
