摘要
目的探讨葛根骨康宁颗粒对去势大鼠骨密度的作用。方法清洁级雌性SD大鼠60只,随机分成6组:葛根骨康宁颗粒低、中、高剂量组(0.43,0.87,2.60 g.kg-1),碳酸钙对照组、模型对照组及假手术组。12周后,测定动物体重、股骨干重、骨密度和骨钙含量。结果高剂量组股骨中心骨密度、股骨远心端骨密度、股骨干重及骨钙含量显著高于模型对照组(P<0.05)。结论葛根骨康宁颗粒具有增加大鼠骨密度的功能。
Objective To study the effect of Gegeng Gukangning Granule on increasing bone mineral density in ovariectomized rats.Methods Sixty clean Sprague Dawley rats were divided into 6 groups,including low-,moderate-and high-dose Gegeng Gukangning Granule groups（0.43,0.87 and 2.60 g·kg-1,respectively）,calcium carbonate group,model group and sham operation group.After treatment for 12 weeks,the body weight,thighbone weight,bone mineral density and calcium quantity in the bone of rats were measured.Results Body mineral density of the central part and the distal end of the femur as well as the femoral calcium content in the high-dose Gegeng Gukangning Granule group was significantly higher than that in the model control group（P 0.05）.Conclusion Gegeng Gukangning Granule can increase the bone mineral density of ovariectomized rats.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第1期10-13,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省产学研结合项目(2010B090400455)
关键词
葛根骨康宁颗粒
骨质疏松症
骨密度
大鼠
Gegeng Gukangning Granule
Osteoporosis
Bone Mineral Density
Rats
