摘要
目的:优化复方疮疡涂膜剂的提取方法和制备工艺。方法:以绿原酸含量为指标,以加水倍数、煎煮时间、醇沉浓度为考察因素,采用L9(34)正交试验法。制备工艺以成膜性和成膜外观为指标,单因素优选成膜基质和辅料。结果:经方差分析,从而筛选出最优工艺为A3B3C1。最优制备工艺为PVA17-88 11 g,加入PEG-400 2 mL,浓缩药液42 mL,搅拌,浸泡1h,水浴加热溶解,加入95%乙醇42 mL,甘油2 mL,氮酮1 mL,尼泊金乙酯适量,搅匀。结论:该工艺的稳定性良好,绿原酸含量高,成膜性能、外观以及成膜时间均较理想,可以作为该制剂的最优提取工艺。
Objective：To optimize extraction and preparation technology for compound abscess plaster.Method：Extraction technology has chosen the content of chlorogenic acid as index,multiple of added water,boiling time,concentration of alcohol precipitation were as test factors by L9（34）orthogonal test.Samples were determined by HPLC.Preparation technology has chosen film-forming and film appearance as index,and taken One-factor test to find out optimum film-coating agent and accessories.Result：Optimum extraction technology was A3B3C1.Optimal preparation technology was PVA-178 811 g,PEG-4 002 mL,concentrated liquid 42 mL,stired,soaked 1 h,dissolved in hot water,then added 42 mL 95% ethanol,2 mL glycerol,1 mL azone,amount of ethylparaben,stired well.Conclusion：This technology was stable with high content of chlorogenic acid.It was compatible in film-forming,appearance and film forming time.This technology could be chosen as optimum extraction technology.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第2期29-32,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
涂膜剂
提取工艺
制备工艺
金银花
疮疡
film coating agent
extraction technology
preparation technology
Lonicera japonica
abscess
