摘要
目的探讨血清胱抑素C（Cystatinc）在早期诊断危重患者急性肾损伤（AKI）的价值。方法收集重症病房中危重患者资料108例，分为AKI组24例和非AKI组84例，分别用免疫比浊法检测两组血清胱抑素C（CystatinC）、D2微球蛋白（B2-MG）：用酶法检测血清肌酐（Scr）、用公式计算肾小球滤过率（eGFR），比较两组患者上述指标的差异。结果AKI患者的CystatinC水平、B2-MG水平和Scr水平均较非AKI患者显著升高（P〈O．05）；AKI患者的CystatinC与Scr呈正相关（r=0．662，P〈O．01），AKI组患者的CystatinC水平与B2-MG呈正相关，（r=0．569，P〈0．01），（CystatinC）-1与eGFR呈正相关（r=0．808，P〈0．01）。AKI患者的CystatinC水平早于Scr和B2-MG出现异常，CystatinC诊断AKI的灵敏度明显优于Scr和B2-MG（P〈0．05）。结论危重患者发生AKI时，血清CystatinC显著升高，且Cysta-tinc较Scr和B2-MG更敏感、更准确地反映危重患者早期肾功能的损害，可作为危重患者并发AKI的早期诊断指标之一。
Objectives To explore the early diagnostic value of serum Cystatin C in acute kidney injury （AKI） with the detection of critical patients. Methods The 108 patients coming from the severe case patients＇ rooms are divided into two groups;24 cases are AKI, 84 cases are NAKI. Cystatin C in blood serum detected by immunoturbidimetry , 62 -MG, Scr checked by enzymic method, eGFR by formula calculation are choosed to compare the difference in the two groups. Results Comparing with the NAKI, the AKI patients are significantly high in the level of Cystatin C, β2 -MG, Scr（ P 〈0.05） ;Cystatin C is in positive correlation with Scr （ r =0. 662, P 〈0. O1 ） and 62 - MG （r = 0. 569, P 〈0. 01 ） ,also with eGFR（ r = 0. 808, P 〈 0. 01 ）. The level of Cystatin C is earlier to show the abnormity and more susceptible than Scr andS2 -MG（ P 〈 O. 05 ） . Conclusions When the patients in danger proceed to AKI, the Cystatin C in blood serum will be significantly high, and Cystatin C can reflect the early renal function injury in sever patients more sensitive and more accurately than Scr, 62 - MG. So It can be one of the early diadynamic criteria in the sever patients with AKI.
出处
《国际泌尿系统杂志》
2012年第1期55-58,共4页
International Journal of Urology and Nephrology
基金
基金项目：广西科技攻关课题（桂科攻0898005）
