摘要
目的观察Notch信号在肾透明细胞癌中的表达及临床意义。方法采用Real-timePCR法检测32例肾透明细胞癌组织和32例癌旁正常肾组织Notch信号通路中Notch1及Jag-ged1的表达水平,分析其与临床病理指标之间的关系。结果 Notch1及Jagged1 mRNA在肾透明细胞癌组织的表达分别为(0.53±1.48)、(0.15±0.59),均低于正常肾组织(P<0.05);Notch1的表达与肿瘤临床分期、病理组织分级有关(P<0.05)。结论 Notch信号通路表达失调与肾癌的发生。
Objective To explore the expression and significant of Notch signaling pathway in suprarenal epithelioma.Methods To test the expression levels of Notch signaling pathway receptor Notch1、ligand Jagged1 by real-time PCR in 32 samples of suprarenal epithelioma and 32 samples of cancer-adjacent normal tissues.The correlation between Notch signal and clinicopathologic indexes was analyzed.Results The expression levels of Notch1、Jagged1 mRNA in suprarenal epithelioma were（0.53±1.48）and（0.15±0.59）respectively.Compared with cancer-adjacent normal tissues,the difference was statistically significant（P0.05）.The expressions of Notch1 were closely related to clinical stages and pathologic grade of suprarenal epithelioma（P0.05）.Conclusion the expression of the notch signaling pathway may be correlated to the occurrence and development of suprarenal epithelioma.
出处
《山东医学高等专科学校学报》
2011年第6期405-407,共3页
Journal of Shandong Medical College
基金
山东医学高等专科学校资助课题(No.SYKJ2010003)
