摘要
目的:探讨汉族与维吾尔族三阴性乳腺癌患者临床特征及预后,了解两民族三阴性乳腺癌临床特征的差异。方法:选取2003年1月至2005年1月新疆肿瘤医院收治的可手术切除并经病理证实的458例汉、维族乳腺癌患者,将ER、PR、Her-2表达均阴性的患者,分为汉族及维族两组,比较两组临床特征、复发转移情况及5年无瘤生存率。结果:458例乳腺癌患者当中,其中97例维吾尔族患者,361例汉族患者,三阴性乳腺癌总例为108例,所占比例为23.6%(108/458)。108例三阴性乳腺癌患者中,维吾尔族患者28.9%(28/97),汉族患者为22.2%(80/361)。两组在肿瘤大小及临床分期方面差异有统计学差异(P<0.05),但两者的复发转移模式及5年无瘤生存率无明显差别。结论:维吾尔族三阴性乳腺癌患者就诊时较汉族患者偏晚,T_3期所占比例要高于汉族患者,T_1期比例低于汉族患者,同时Ⅲ期患者比例明显高于汉族患者。但两组5年无瘤生存率无差别,应采取进一步研究以明确影响汉、维族三阴性乳腺癌患者的预后因素。
Objective： To investigate the characteristics and differences in the clinical characteristics and prognosis of triple-negative breast cancer between the Han and Uygur ethnic groups. Methods： Clinical data of 458 operable patients of the Han and Uygur eth- nic groups confirmed histo-pathologically that were treated at Xinjiang cancer hospital between January 2003 and January 2005 were analyzed. Triple-negative breast cancer patients were confirmed in the two groups and were analyzed with respect to clinical features, recurrence, and 5-year disease-free survival （ DFS ）. Results： Out of the 458 patients, which included 97 Uygur patients and 361 Han Chinese patients, 108 patients （ 23.6%, 108/458 ） were confirmed to have triple-negative breast cancer. Moreover, the triple-negative breast cancer rate in the Uygur and Han patients was 28.9% （ 28/97 ） and 22.2% （ 80/361 ）, respectively. The two groups had statistical- ly significant differences in tumor size and clinical stage （ P 〈 0.05 ）, however, the recurrence rate and 5-year DFS in the two groups were not significantly different from each other. Conclusion： The Urgur patients were diagnosed with late-stage cancer compared with the Han patients. The Urgur patients had higher proportions of T3 than the Han patients. Moreover, the Urgur patients had lesser propotions of T1 than the Han patients, whereas the proportion of the Uygur patients in stage III was significantly higher than that of the Han patients. However, no differences were found between the two groups. Further research should be taken to investigate the effects of prognostic factors between the Han and Uygur patients with triple-negative breast cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2011年第24期1579-1583,共5页
Chinese Journal of Clinical Oncology
基金
新疆医科大学科研创新基金项目(编号:XJC201033)资助~~
关键词
汉族
维族
三阴性乳腺癌
临床特征
预后
Han and Uygur
Triple-negative breast Cancer
Clinical feature
Prognosis
