摘要
目的分析极低出生体重儿(VLBWI)急性肾损伤(AKI)的发病情况、危险因素和预后。方法将87例VLBWI分为无AKI组54例和AKI组33例。参照急性肾损伤网络(AKIN)诊断标准进行AKI分期、危险因素及预后的判断。结果符合AKI诊断标准33例(37.9%)中,AKI1期14例(16.1%),2期10例(11.5%),3期9例(10.3%)。AKI组患儿病死率明显高于无AKI组患儿(51.5%vs.5.6%)(P<0.01)。病死率:AKI 1期组21.4%,2期组60.0%,3期组88.9%,均高于无AKI组的5.6%(P<0.01)。多因素Logistic回归分析显示,围生期窒息、医院感染败血症、呼吸窘迫综合征和机械通气≥3d是VLBWI发生AKI的独立危险因素。结论 VLBWI有较高的AKI发生率,AKIN分期对VLBWI发生AKI的早期诊断和判断预后有重要的指导意义。
Objective To analyze the incidence,risk factors and prognosis of acute kidney injury（AKI） in very low birth weight infants（VLBWIs）.Methods Clinical data of 87 VLBWIs were retrospectively analyzed.AKI was diagnosed by the Acute Kidney Injury Network（AKIN）,based on which the VLBWIs were assigned into two groups of A（33 cases,with AKI） and B（54 cases,without AKI）.Results Of 33 AKI infants,14 cases（16.1%） were in stage 1,10 cases（11.5%） in stage 2,9 cases（10.3%） in stage 3.Mortality was much higher in group A than that in group B（51.5% vs.5.6%）（P0.01）.The mortality rates of AKIN stage 1,2 and 3 in group A were 21.4%,60.0% and 88.9%（P0.01）,respectively,which were all higher than 5.6% in group B（P0.01）.The perinatal asphyxia,nosocomial sepsis,acute respiratory distress syndrome and mechanical ventilation≥3 days were the independent risk factors for developing AKI in VLBWIs.Conclusion The VLBWIs have a higher incidence of AKI.AKIN staging is valuable in early diagnosis and predicing the prognosis of AKI in the VLBWIs.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第24期2933-2935,共3页
Jiangsu Medical Journal
关键词
极低出生体重儿
急性肾损伤
Very low birth weight infants
Acute kidney injury
