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MiR-146a在免疫反应中的调节作用 被引量:1

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摘要 microRNA是一类非编码的小分子RNA,通过在转录后水平抑制蛋白的表达,在许多生理和病理进程中发挥重要作用。MiR-146a在固有免疫调节、炎症反应以及抗病毒中发挥重要作用。本文就最近对miR-146a在固有免疫、炎症应答、病毒感染和人类疾病等方面的研究进行了综述。研究显示,可能可以通过对miR-146a表达的调控来治疗一些人类疾病。
出处 《热带医学杂志》 CAS 2011年第12期1447-1449,共3页 Journal of Tropical Medicine
基金 国家自然科学基金(U0832006 30972763) 国家教育部博士点基金(2010017111004) 广东省自然科学基金(10251008901000013)
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参考文献10

  • 1Pedersen IM,Cheng G,Wieland S,et al.Interferon modulation of cellular microRNAs as an antiviral mechanism[J].Nature,2007,449(7164):919-922. 被引量:1
  • 2Motsch N,Pfuhl T,Mrazek J,et al.Epstein-Barr virus-encoded latent membrane protein1(LMP1)induces the expression of the cellular microRNA miR-146a[J].RNA Biol,2007,4(3):131-137. 被引量:1
  • 3Dai R,Phillips RA,Zhang Y,et al.Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs:a novel mechanism of immune modulation[J].Blood,2008,112(12):4591-4597. 被引量:1
  • 4El GM,Church A,Liu T,et al.MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-{alpha}during TLR4-induced gene reprogramming[J].J Leukoc Biol,2011,90(3):509-519. 被引量:1
  • 5Poy MN,Eliasson L,Krutzfeldt J,et al.A pancreatic islet-specific microRNA regulates insulin secretion[J].Nature,2004,432(7014):226-230. 被引量:1
  • 6Bhaumik D,Scott GK,Schokrpur S,et al.Expression of microRNA-146suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells[J].Oncogene,2008,27(42):5643-5647. 被引量:1
  • 7Young LS,Murray PG.Epstein-Barr virus and oncogenesis:from latent genes to tumours[J].Oncogene,2003,22(33):5108-5121. 被引量:1
  • 8Hou J,Wang P,Lin L,et al.MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6,IRAK1,and IRAK2[J].J Immunol,2009,183(3):2150-2158. 被引量:1
  • 9Zhang H,Luo XQ,Zhang P,et al.MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia[J].PLoS One,2009,4(11):e7826. 被引量:1
  • 10王海燕,李扬,陈梅红,张烜.系统性红斑狼疮患者外周血单个核细胞中微小RNA-146a的表达[J].中国医学科学院学报,2011,33(2):185-188. 被引量:8

二级参考文献8

  • 1Brennecke J, Hipfner DR, Stark A, et al. Bantam encodes a developmentally regulated microRNA that controls cell prolif- eration and regulates the proapoptotic gene hid in drosophila [J]. Cell, 2003, 113(1) :25-36. 被引量:1
  • 2Kawasaki H, Taira K. Hesl is a target of microRNA-23 dur-ing retinoic-aeid-indueed neuronal differentiation of NT2 ceils [J]. Nature, 2003, 423(6942):838-842. 被引量:1
  • 3Albino AP, Juan G, Traganos F, et al. Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid : associ- ation with decreased pRb phosphorylation [ J ]. Cancer Res, 2000, 60(15) :4139-4145. 被引量:1
  • 4Kaleb MP, Minoru S, Annie 146a expression in peripheral LC, et al. Upregulated miR- blood mononuclear cells from rheumatoid arthritis patients [ ] ]. Arthritis Res Ther, 2008 10(4) :101-110. 被引量:1
  • 5Konstantin DT, Mark PB, Kuang JC, et al. NF-KB-depend- ent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [ J ]. PNAS, 2006, 103(33) :12481-12486. 被引量:1
  • 6Mark MP, Sterghios AM, Andrew EW, et al. Rapid changes in microRNA-146a expression negatively regulate the interleu- kin-1β induced inflammatory response in human lung alveolar epithelial cells [J]. J Immunol, 2005, 180(8) :5689-5698. 被引量:1
  • 7Barrel DP. MicroRNAs: genomics, biogenesis, mechanism, and function [ J ]. Cell, 2004, 116 ( 2 ) :281-297. 被引量:1
  • 8Ambros V. The functions of animal microRNAs [ J]. Nature, 2004, 431 (7006) :350-355. 被引量:1

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