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不同压力控制性肺膨胀对内源性急性肺损伤疗效分析 被引量:3

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摘要 目的探讨不同压力控制性肺膨胀(SI)对内源性急性肺损伤(ALI)的疗效。方法选用健康新西兰兔20只,随机分为5组,每组4只。C组:空白对照,仅行气管插管;P0、P1、P2、P3组:气管内注入生理盐水致ALI,并分别采用0、30、35、40 cmH2O压力进行肺复张。记录实验动物造模前、后和肺复张后30 min的气体交换、呼吸力学指标。结果对于肺内源性ALI家兔,SI压力为30 cmH2O时氧合并未有明显改善,仍低于300 mmHg,当压力为35cmH2O和40 cmH2O时氧合改善较好,且两者间差异无统计学意义。以35 cmH2O的压力实施SI时,家兔肺动态顺应性(Cdyn)增加;而压力提高至40 cmH2O时,Cdyn并不进一步增加。结论 35 cmH2O为实施SI治疗内源性急性ALI的适合压力。
出处 《山东医药》 CAS 北大核心 2011年第52期37-38,共2页 Shandong Medical Journal
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参考文献5

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