摘要
目的探讨先天性心脏病(CHD)合并感染性心内膜炎(IE)的病原学分布及其耐药状况,为指导临床选择抗生素提供依据。方法选择沈阳军区总医院1997年1月—2009年12月收治的73例IE患者进行血培养,分析病原学种类及药敏试验结果。结果术前血培养及术中赘生物细菌培养总阳性率23.3%(17/73)。感染细菌以草绿色链球菌为主,其次为金葡菌、肠球菌和口腔链球菌。结论 CHD合并IE病原菌菌种呈现多样化趋势,积极加强对IE患者的血培养检查和药敏试验极为重要。传统的经验性应用大剂量青霉素治疗的观念需要改变。
Objective To analyze the distribution and resistance of pathogenic microorganisms in infective endocarditis （IE） patients with congenital heart disease in order to improve the antimicrobial therapy. Methods Seventy-three IE patients with congenital heart disease treated in our hospital from January 1997 to December 2009 were included in this analysis. The pathogenic microorganisms were isolated by blood culture, identified and tested for antibiotic susceptibility. Results The overall positive rate of culture was 23.3% , including preoperative blood culture and intraoperative vegetation culture. The bacterial pathogen was mainly Streptococcus viridans, followed by Staphylococcus aureus, Enterococcus, and Streptococcus oralis. Conclusions The pathogen in IE patients with congenital heart disease appears complex. It is vital to carry out proactive blood culture and antimicrobial susceptibility testing. The conventional empirical high dose penicillin regimen is no longer appropriate.
出处
《中国感染与化疗杂志》
CAS
北大核心
2012年第1期1-4,共4页
Chinese Journal of Infection and Chemotherapy
