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p21活化激酶4与肿瘤的研究进展 被引量:2

p21 activated kinase 4 and tumor
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摘要 p21活化激酶4(PAK4)是最近发现的一种丝氨酸/苏氨酸蛋白激酶,在一系列细胞功能中发挥重要作用,如细胞周期、细胞增殖、细胞凋亡及细胞骨架重组等。近年研究发现,PAK4在许多肿瘤细胞中过表达,并通过多条信号通路参与肿瘤的发生及迁移浸润。 p21 activated kinase 4 (PAK4) is a member of a family of serine/threonine kinase. PAK4 plays an important role in a variety of cellular functions including cell cycle, cell proliferation, apoptosis, and cytoskeletal reorganization. Recently, PAK4 has been shown to overexpress in a variety of malignancies, and contribute to cancer cell migration and invasion through multiple signalling pathways.
出处 《国际肿瘤学杂志》 CAS 2012年第1期15-18,共4页 Journal of International Oncology
基金 基金项目:国家自然科学基金资助项目(30973377) 广东省自然科学基金资助项目(9151800102000000) 广东省高等学校人才引进项目(粤教师[2008]86号) 广东省科学计划国际合作项目(20098050200013)
关键词 p21活化激酶4 肿瘤 细胞周期 p21 activated kinase 4 Neoplasms Cell cycle
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参考文献23

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