摘要
目的探讨使用不同的血液净化方式治疗脓毒症导致的急性肾损伤的疗效对比及其机理。方法参与治疗实验的患者均须建立临时的血管通路,本实验全部为股静脉置管。①CBP组28例患者,采用连续性的静脉-静脉血液透析滤过方法。置换液选择碳酸盐溶液,以前/后稀释的方式输入,透析液采用碳酸氢盐溶液,流量为1200ml/h。每日治疗时间10h,置换液的量必须大于32L。②IHD组28例,采用中空的纤维聚砜膜透析仪,透析液为碳酸氢盐溶液,每周透析3次以上,平均4h。结果连续性血液净化(CBP)组和间歇性血液透析(IHD)组治疗前后的尿素氮(BUN)和血肌酐(SCr)均有明显的下降,其差异有统计学意义(P<0.05);但是连续性血液净化(CBP)组治疗之后的尿素氮(BUN)和血肌酐(SCr)血浆浓度均比间歇性血液透析(IHD)组的尿素氮(BUN)和血肌酐(SCr)血浆浓度低,其差异有统计学意义(P<0.05)。结论连续性血液净化(CBP)和间歇性血液透析(IHD)都对急性肾损伤有治疗效应,但是CBP的疗效明显优于IHD的疗效。
Objective To explore the efficacy contrast of use of different blood purification treatment of sepsis causing acute kidney damage and its mechanism.Methods The patients involved in experimental treatment are required to establish temporary ascular access,this experiment all for femoral venous catheter.① the CBP group of 28 patients,the continuity of vein-vein blood Hemodiafiltration method.Replacement liquid choose carbonate solution,after the way before/diluted input,Dialysate liquid choose carbonate solution,the flow is 1200ml/h.The daily treatment time 10 hours,the amount of fluid replacement must be more than 32 L.②28 cases IHD group,the hollow fiber membrane dialysis machines were together,dialysis for bicarbonate solution,dialysis three times or more a week,an average of 4 hours.Results Continuity blood purification（CBP） group and intermittent hemodialysis（IHD） before and after treatment group of urea nitrogen（BUN） and blood creatinine（SCr） are a marked decline,the difference was statistically significant（P〈0.05）;But continuity blood purification（CBP） after treatment group of urea nitrogen（BUN） and blood creatinine（SCr） plasma concentrations are better than intermittent hemodialysis（IHD） group of urea nitrogen（BUN） and blood creatinine（SCr） plasma concentration is low,the difference was statistically significant（P〈0.05）.Conclusions Continuity blood purification（CBP） and intermittent hemodialysis（IHD） are acute kidney injury to have treatment effect,but the effect of CBP significantly better than IHD curative effect.
出处
《医药论坛杂志》
2011年第21期17-19,共3页
Journal of Medical Forum
关键词
脓毒症
急性肾损伤
连续性血液净化
间歇性血液透析
Sepsis
Acute kidney injury
Continuity blood purification
Intermittent hemodialysis
