摘要
目的研究降压治疗中使用β受体阻滞剂对血脂的影响。方法将101例高血压病1～2级患者随机分为普萘洛尔组51例和比索洛尔组50例。普萘洛尔组给予普萘洛尔5～10mg,每天3次;比索洛尔组给予比索洛尔5～10mg,每天1次。治疗前及治疗2个月后采空腹静脉血检查血三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平。结果普萘洛尔组治疗后TG升高、HDL-C下降,治疗前后比较差异有统计学意义(P<0.05)。比索洛尔组治疗后TG、HDL-C水平改变不明显,治疗前后比较差异无统计学意义(P>0.05)。2组治疗前后LDL-C无明显变化,差异无统计学意义(P>0.05)。结论在降压治疗中使用β受体阻滞剂对血脂有一定影响,而高选择性β1受体阻滞剂对血脂无明显不良影响。
Objective To study the influence of β-blockers to blood lipid in anti-hypertensive treatment. Methods 101 cases patients were randomized into propranolol group（51 cases） and bisoprolol group （50 cases）. Propranolol group were given propranolol 5 - 10mg, three times a day;Bisoprolol group were given bisoprolol 5 - 10mg, one time a day. Detected the value of the TG, LDL-C, HDL-C of two groups before and after treatment. Results Propranolol group after treatment, TG increased, HDL-C dropped, the difference was statistically significant （ P 〈 0.05 ）. Bisoprolol group after treatment, the level of TG, HDL -C was not statistically significant （P 〉 0.05 ）. Before and after treatment, the level of LDL-C of two groups was no significant change, the difference was not statistically significant （ P 〉 0.05 ）： Conclusion The β-blockers has significent influence to blood lipid in anti-hypertensive treatment, but there is no significent influence to blood lipid with high-speclity β- blockers treantment.
出处
《临床合理用药杂志》
2011年第23期3-4,共2页
Chinese Journal of Clinical Rational Drug Use
