摘要
目的了解本地区宫颈疾病妇女的人乳头状瘤病毒(HPV)感染现状,对HPV防治提供流行病学数据。方法采用导流杂交基因分型技术搜集2008年5月～2011年9月1 008例来我院就诊的宫颈疾病患者宫颈脱落细胞标本进行HPV检测及基因分型,分析HPV南海地区宫颈疾病妇女感染率以及不同亚型HPV感染率,研究不同HPV亚型在不同人群中的分布等。结果 1 008例宫颈疾病患者HPV阳性数为252例,感染率为25%(252/1 008),复合感染率为5.7%(58/1 008),HR-HPV感染率为20.9%、其亚型分布最为常见是HPV16(6.2%)和52(6.1%),其次是HPV58(3.8%)、18(2.0%)、33(1.8%),LR-HPV感染率为5.6%、其亚型分布主要是HPV53(5.4%)、11(4.0%),其次是HPV6。以20～40岁年龄段感染率为最高;宫颈炎症以HPV16、58、11为主,宫颈不典型增生以HPV16、52、58为主,宫颈癌以HPV16为主。结论 HPV在佛山南海区宫颈疾病妇女生殖道的感染率及重叠感染率较文献报道低,不同宫颈疾病优势型别不同,故HPV感染应该引起社会的重视,加强常规检测HPV,以早期发现感染,及时干预。
Objective To study the relationship of human papillomavirus（HPV） infection and disease of uterine cervix in women in Foshan region and analyze the key risk factors of high risk（HR）-HPV infection. Methods A total of 1008 patients with disease of uterine cervix were investigated,and the cast-off cells samples of cervix uteri were collected.Meanwhile the clinical data and laboratory results of these patients were gathered.The cast-off cells samples of cervix uteri were detected genotype of HPV with the flow-through hybridization technique（HybriMax）. Results The cast-off cells samples of cervix uteri in 1008 cases were detected,and it showed 252 patients were with HPV infection（25.0%）,consisting of patients infecting HR-HPV（20.9%） and 58 patients were infected with the superinfection of HPV（5.7%）.The typical infection spectra of HPV in women with the disease of uterine cervix were mostly of HPV16（6.2%）,HPV52（6.1%）,then HPV58（3.8%）,HPV18（2.0%）,HPV33（1.8%）;LR-HPV infection rate is 5.6%,its genotype is mainly HPV53（5.4%）、11（4.0%）,and then HPV-6.Most high infection rate is seen in 20-40 years old;The infection spectra of cervicitis were mostly HPV16,HPV58,and HPV11,that of cervix uteri were mainly HPV16,HPV52,and HPV58,and that of cancer of the cervix were principally HPV16. Conclusion The infection rate and superinfection rate of HPV from women with disease of uterine cervix in Foshan region are not so high as literature reported.The superiority of genotype in different uterine cervix disease is not the same.So the HPV infection should bring to society＇s attention and enhance the conventional examination of HPV.
出处
《现代医院》
2011年第12期20-22,共3页
Modern Hospitals
