摘要
目的研究扶正口服液(Fuzheng Oral Mesicinal Liquis,以下简称FZ)对由对乙酰氨基酚(Acetaminophen,AP)引起的小鼠肝损伤的保护作用。方法以AP诱发小鼠肝损伤模型,采用灌胃法给予FZ,测定小鼠血清丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、总蛋白、白蛋白及球蛋白的水平,并做肝脏病理切片。结果与模型组相比,各剂量组FZ均能降低小鼠ALT、AST水平。大剂量组(40 g/kg)能促进白蛋白的分泌,降低球蛋白水平,白/球比值有一定升高。病理切片显示,AP模型组肝细胞呈带状坏死,肝细胞呈弥漫性变化,FZ大剂量组肝小叶结构完整、清晰,少量细胞点状坏死,肝脏组织病理损伤明显减轻。结论FZ对AP致小鼠肝损伤具有一定的保护作用。
Objective To study the protective effect of Fuzheng oral mesicinal liquid（FZ） on the murine liver injured by acetaminophen. Methods A murine model of liver injury induced by acetaminophen（AP） served as the subject of the study.The levels of aminotransferase（ALT and AST）,total protein,albumin,globulin in serum were determined after they were given FZ by irrigation stomach method and hepatic histopathology was also studied. Results Compared with model group,each dose group of FZ had reduced AST,ALT levels in serum of the mice.40 g/kg group could promote the secretion of albumin,reduce globulin level and A/G ratio was raised.Pathological sections revealed zonular necrosis and diffuse anomalies of hepatic cells in the liver of the AP murine model.In the liver of mice treated with large dosed of FZ,the structure of the lobule of liver was intact and clear,punctate necrosis of only a few hepatocytes was demonstrated.The liver tissue of pathological damage was reduced obviously. Conclusion FZ oral liquid had a certain protective effect on the liver injured by AP in mice.
出处
《现代医院》
2011年第12期16-17,共2页
Modern Hospitals
