期刊文献+

人尿激肽原酶治疗老年急性脑梗死疗效观察 被引量:2

下载PDF
导出
摘要 目的观察人尿激肽原酶(尤瑞克林)对老年急性脑梗死患者的临床疗效。方法选取62例急性脑梗死患者,年龄介于60~75岁之间,随机分为两组。对照组给予一般常规治疗,治疗组在常规治疗基础上给予尤瑞克林0.15PNA单位静脉滴注,1次/d,两组疗程均为14d,分别于治疗前后采用美国国立卫生院卒中量表(NIHSS)评价患者神经功能缺损的变化情况。并在治疗后90d随访时用改良Rankin量表(mRS)评定患者临床预后及独立生活能力。结果尤瑞克林组临床有效率为84.4%,对照组为60.0%,两组比较,差异有统计学意义;据mRS评分评估患者预后,尤瑞克林组预后良好比率亦高于对照组。结论人尿激肽原酶能有效的改善老年急性脑梗死患者的神经功能缺损及临床预后。
出处 《当代医学》 2012年第2期135-136,共2页 Contemporary Medicine
  • 相关文献

参考文献13

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33004
  • 2Chacon MR,Jensen MB,Sattin JA,et al.Neuroprotection in cerebral ischemia:emphasis on the SAINT trail[J].Curr Cardiol Rep,2008,10(1):37-42. 被引量:1
  • 3Ole-MoiYoi OK,Spragg J,Austen KF.Structural studies of human urinary kallikrein (urokallikrein)[J].Proc Natl Acad Sci USA,1979,76(7):3121-3125. 被引量:1
  • 4Lu HS,Lin FK,Chao L,et al.Human urinary kallikrein.Complete amino acid sequence and sites of glycosylation[J].Int J Pept Protein Res,1989,33(4):237-249. 被引量:1
  • 5Nagano H,Suzuki T,Hayashi M,et al.Effects of a human urinary kininogenase (SK-827) on cerebral microcirculation after glass beadinduced cerebral embolism in rabbits[J].In Vivo,1992,6(5):497-502. 被引量:1
  • 6Nagano H,Suzuki T,Nakamura S,et al.Pharmacological studies on human urinary kallidinogenase (SK-827):cerebral protective effects[J].Yakugaku Zasshi,1993,113(11):803-809. 被引量:1
  • 7Nagano H,Suzuki T,Tomoguri T,et al.Pharmacological studies on human urinary kallidinogenase (SK-827):effects on cerebral metabolism[J].Yakugaku Zasshi,1993,113(11):825-828. 被引量:1
  • 8Nagano H,Suzuki T,Hayashi M,et al.Effects of a human urinary kininogenase (SK-827) on cerebral and cutaneous microcirculation in rabbits[J].In Vivo,1993,7(2):117-119. 被引量:1
  • 9Emanueli C,Madeddu P.Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases[J].Arch Mal Coeur Vaiss,2004,97(6):679-687. 被引量:1
  • 10Xia CF,Yin H,Borlongan CV,et al.Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis[J].Hypertension,2004,43(2):452-459. 被引量:1

二级参考文献1

共引文献33135

同被引文献25

  • 1周沐科,何俐,孔双艳.人尿激肽原酶治疗急性脑梗死的随机双盲对照试验[J].华西药学杂志,2006,21(4):356-358. 被引量:10
  • 2丁德云,吕传真,丁美萍,苏炳华,陈峰.人尿激肽原酶治疗急性脑梗死多中心随机双盲安慰剂对照试验[J].中华神经科杂志,2007,40(5):306-310. 被引量:169
  • 3Jiang,Z.,Sun,J.,Liang,Q.et al.A metabonomic approach applied topredict patients with cerebral infarction[J].Talanta,2011,84(2):298-304. 被引量:1
  • 4Zhang,B.,Gao,C.,Hou,Q.,et al.The potent different risk factors forcerebral infarction in young patients with and without type 2 diabetes:Subanalysis of the Young Cerebral Infarction Study(YCIS)[J].Atherosclerosis,2012,221(1):215-220. 被引量:1
  • 5Donati,G.,Coli,L.,Cianciolo,G.et al.Thrombosis of tunneled-cuffed hemodialysis catheters:Treatment with high-dose urokinaselock therapyfj].Artificial Organs,2012,36(1):21-28. 被引量:1
  • 6Manninen,H.,Juutilainen,A.,Kaukaneni E,et al.Catheter-directedthrombolysis of proximal lower extremity deep vein thrombosis:Aprospective trial with venographic and clinical follow-up[J].EuropeanJournal of Radiology,2012,81(6):1197-1202. 被引量:1
  • 7Chen ZB,Huang DQ,Niu FN,et al.Human urinary kallidinogenasesuppresses cerebral inflammation in experimental stroke anddownregulates nuclear factor-kappaB.[J].Journal of Cerebral BloodFlow and Metabolism,2010,30(7):1356-1365. 被引量:1
  • 8Tsuji,S.,Kasumi,T.,Nagase,K,et al.The effects of amino-acidmutations on specific interactions between urokinase-typeplasminogen activator and its receptor:Ab initio molecular orbitalcalculations[J].Journal of molecular graphics & modelling,2011,29(8):975-984. 被引量:1
  • 9Shwetha K.Shetty,Amamath S.Marudamuthu,Daniel Abernathy,etal.Regulation of Urokinase Expression at the Posttranscription Levelby Lung Epithelial Cells[J].Biochemistry,2012,51(1):205-213. 被引量:1
  • 10Chen,H.,Teramura,Y.,Iwata,H.,et al.Co-immobilization ofurokinase and thrombomodulin on islet surfaces by poly(ethyleneglycol)-conjugated phospholipid[J].Journal of Controlled Release,2011,150(2):229-234. 被引量:1

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部