摘要
目的：观察尼扎替丁治疗老年胃食管反流病的疗效。方法：将１１６例老年胃食管反流病随机分为３组：Ａ组 ４０例８组 ３８例（组 ３８例，分别应用奥美拉唑 ２０ ｍｇ。尼扎替 丁 １５０ ｍｇ。雷尼替丁１５０ ｍｇ，ｂｉｄ × ４周；然后分别改为２０ ｍｇ、１５０ ｍｇ、１５０ｍｇ ｑｄ至 ６个月．于治疗 ４周、３月、６月后观察各组总有效率。结果：显示 Ｂ组 ４周、３月、６月总有效率分别为８１．５８％、８９．４７％。９４．４７％，与Ａ组相比（分别为８５．００％、９０．００％、９５．００％）无显著性差异（Ｐ＞０．０５）；而与Ｃ组相比（分别为 ６５．７９％。７６．７２％、７８．９５％）有显著性差异（Ｐ＜０．０５）。症状积分与总有效率结果一致。结论：尼扎替丁治疗老年胃食管反流病与奥美拉唑疗效相仿，优于雷尼替丁，且价廉、副作用少。
Purpose: To observe the efficacy of nizatidine in the treatment of gastroesophageal reflux disease in elderly. Methods: 116 patients with gastroesophageal reflux disease in elderly were randomly di- vided into 3 groups: 40 patients was treated with omeprazole 20 mg bid for 4 wk; 38 patients was treated with nizatidine 150 mg bid for 4wk; 38 patients was treated with ranitidine 150 mg bid for 4wk, then de- creased to omeprazole 20mg, qd, and nizatidine 150 mg pd, and ranitidine 150 mg, qd. for 6 mo. Observ- ing the efficacy in the course of treatment 4wk, 3mo, 6mo. Results: The total effective rates of nizatidine and omeprazole were 81. 58 %, 89. 47 %, 94. 47 % and 85. 00 %, 90. 00 %, 95. 00 % in the course of treat- ment 4wk, 3mo, 6mo (P > 0. 05 ). The total effective rates of ranitidine were 65. 79 %, 76. 72 %, 78. 95 %. They were significant difference (P < 0. 05) in the nizatidine and ranitidine. The result of symptom score was accordance with that of the total effective rates. Conclusion: The efficacy of nizatidine is similar to that of omeprazole and nizatidine is more effective than ranitidine in the treatment of gastroesophageal re- flux disease in elderly. It is a cheap and safe drug.
出处
《临床消化病杂志》
2000年第1期20-22,共3页
Chinese Journal of Clinical Gastroenterology
