摘要
目的:观察糖前康胶囊对糖耐量减低患者颈动脉中膜厚度、血液流变学及血脂的影响。方法:采用随机、单盲平行对照的试验设计方法,以口服75 g葡萄糖耐量试验(OGTT)筛选,按1999年WHO诊断标准判定的120例患者进行研究。按就诊顺序随机分分治疗组与对照组,每组60例。治疗组给予口服糖前康胶囊,3粒/次,3次/d;对照组给予口服二甲双胍,0.25 g/次,3次/d;治疗前和治疗12周后分别检测2组患者的颈动脉中膜厚度、血液流变学和血脂。结果:治疗组和对照组对糖耐量减低患者都具有改善血液流变学、血脂和降低颈动脉中膜厚度作用,但治疗组优于对照组(P<0.05)。结论:糖前康胶囊具有降低糖耐量,减低患者颈动脉中膜厚度及调节血液流变学、血脂的作用,是预防和治疗糖耐量减低患者向2型糖尿病转变的有效药物。
Objective：Effect of TangQianKang capsule for carotid intimamedia thickness、bloodrheology、blood lipids of impaired glucose tolerance（IGT）patient.Method：A randomized,single-blinded,placebo controlled,parallel-group trial was used in the study.120 patients diagnosed according to the standard of WHO（1999） were screened by oral glucose tolerance test（OGTT）,and their data were retrospectively analyzed.120 patients were randomly divided into two groups,observation group and control group,each group had 60 cases.The 60 patients in observation group were treated by TangQianKang capsule 3 pills once,three a day;the other 60 patients in control group were given with Metformin 1 pills with 0.25mg once,three a day,with a treatment course of 12 weeks for both groups.The observed indexes included carotid intimamedia thickness、bloodrheology、blood lipids,changes of prior treatment and post-treatment were observed for both groups.Result：Comepared with pretreatment,the improve to loodrheology、blood fat,degrade of carotid intimamedia thickness for both groups,but therapy group surpass control group（P0.05）.Conclusion：Intervention treatment with TangQianKang capsule was one of the effective measures preventing the conversion of IGT to Type 2 diabetes mellitus.
出处
《西部中医药》
2011年第12期13-16,共4页
Western Journal of Traditional Chinese Medicine
关键词
糖前康胶囊
糖耐量减低
颈动脉中膜厚度
血液流变学
血脂
TangQianKang capsule
IGT
tunica media thickness of artericarotis
blood rheology
blood fat
