摘要
目的探讨甲巯咪唑治疗甲状腺功能亢进症致白细胞减少的原因及治疗。方法回顾性总结应用甲巯咪唑治疗甲状腺功能亢进症导致白细胞减少症患者60例的临床资料。结果60例患者发生白细胞减少时间均在服药治疗第1～6周内，患者（60／60）均发生在服甲巯咪唑15～30mg／d治疗阶段。60例患者中有6例因粒细胞缺乏改用131I治疗；25例经升高白细胞治疗1周白细胞计数、中性粒细胞计数达标；28例治疗2周逐渐恢复正常；1例治疗4周恢复正常。总有效率为98．3％。结论药物毒性及遗传易感性可能是甲巯咪唑致白细胞减少的主要原因，一旦发生，应予以及时处理。
Objective To investigate causes and remedies for Methimazole treatment of hy- perthyroidism- induced leukopenia. Methods Clinical data of 60 patients with the application of Methimazole treatment of hyperthyroidism- induced leukopenia were retrospectively summarized. Results Leukopenia occurred in sixty patients within the first and sixth week of treatment. All these symptoms （60/60） occurred during the intake of Methimazole （15- 30 mg/d）. Due to the lack of granulocyte, 6 patients switched to 131I. 25 patients had normal white blood cell count and neutrophil count 1 week after elevated white blood cell treatment. 28 patients gradually returned to the normal after 2 weeks of treatment. One case returned to the normal in 4 weeks. Conclusion Drug toxicity and genetic susceptibility may be the main cause for Methimazole- induced leucopenia. Once leucopenia occurs, it should be addressed promptly.
出处
《实用临床医药杂志》
CAS
2011年第24期101-103,共3页
Journal of Clinical Medicine in Practice
