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膀胱灌注吡柔比星预防膀胱癌术后复发的临床观察

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摘要 目的:探讨浅表性膀胱肿瘤经尿道膀胱肿瘤电切术后,膀胱灌注吡柔比星预防复发的安全性及疗效。方法:对48例膀胱癌患者行经尿道膀胱肿瘤电切术,术后24 h内即用吡柔比星(30 mg/50 mL)灌注1次,术后1周开始进行膀胱内定期灌注,每次药物在膀胱内保留32 min,每周1次,连续6次,后改为每2周1次,连续6次,最后每月1次,共8次,并随访14~24个月。结果:48例患者均未见明显的全身性药物不良反应,仅6例出现轻微膀胱刺激症状,复发5例,复发率为10.42%。结论:膀胱灌注吡柔比星预防经尿道膀胱肿瘤电切术后复发效果满意,不良反应小,耐受性好。
出处 《山西职工医学院学报》 CAS 2011年第4期31-32,共2页 Journal of Shanxi Medical College for Continuing Education
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