摘要
异基因造血干细胞移植是根治恶性血液病的最有效方法,而移植物抗宿主病(GVHD)是恶性血液病的主要并发症,也是患者移植术后死亡的主要原因。GVHD的口腔表现在所有移植术后并发症中占重要地位,而且对疾病的控制和患者的预后有着举足轻重的影响。本文就GVHD的发病机制、口腔临床表现及其治疗等研究进展作一综述。
Allogenic hematopoietic stem cell transplantation （HSCT） is the most effective treatment for malignant hematologic disease, while graft versus host disease （GVHD） is the main complication and leading cause of mortality in patients receiving HSCT. Oral cavity involvement occurs frequently in patients suffering from GVHD, and it may be the primary or even the only site of GVHD. It is essential for oral professionals to be familiar with various oral GVHD. This review discusses the pathogenesis, multifarious clinical manifestation, available evidence for diagnostic, and the progress of treatment in oral GVHD. The management of the oral GVHD seems to be important in the early diagnosis of GVHD.
出处
《国际口腔医学杂志》
CAS
2012年第1期113-116,共4页
International Journal of Stomatology
基金
浙江省中医药科技计划基金资助项目(2010ZA058)
浙江省医药卫生科学研究基金资助项目(2010KYA068)
教育部留学回国人员科研启动基金资助项目(J20090100)
关键词
移植物抗宿主病
口腔表现
治疗
恶性血液病
graft versus host disease
oral manifestation, treatment
malignant hematologic disease
