摘要
目的观察早期使用地塞米松短程冲击治疗急慢性病毒性肝炎重型倾向患者的近期疗效。方法将我科2008年7月～2010年12月收治的58例急慢性病毒性肝炎重型倾向患者随机分为治疗组和对照组,对照组采用保肝、退黄、抗病毒等常规方法治疗,治疗组在上述常规治疗的基础上加用地塞米松短程冲击治疗。观察两组在治疗2周后肝功能、凝血酶原活动度(PTA)的变化、住院天数、重型肝炎发生率及病死率情况,并进行疗效的评价。结果治疗组2周时患者的TBil明显下降,Alb、PTA明显升高,与对照组相比差异有统计学意义(P<0.05),而ALT、AST与对照组相比差异无统计学意义(P>0.05);治疗组住院时间明显缩短,重型肝炎发生率及病死率均低于对照组,两组相比差异有统计学意义(P<0.05)。结论急慢性病毒性肝炎重型倾向患者早期使用地塞米松短程冲击治疗可有效改善患者肝功能,降低重型肝炎的发生率及病死率,缩短住院时间。
Objective To observe the short - term effect of dexamethasone in the early stage of acute and chronic viral hepatitis in patients with heavy tendency. Methods 65 severe acute and chronic viral hepatitis patients with heavy tendency from the year 2005 to 2010 were randomly divided into treatment group and the control group . The control group was used the conventional methods which included protecting liver, reducing jaundice and antiviral treatment, while the treatment group on the basis of conventional therapy combined with short - term dexamethasone therapy. The liver function, prothrombin activity （PTA） , the total hospital days, severe hepatitis incidence rate and mortality of the two groups were compared after therapy for two weeks. The curative effect was evaluated. Results Compare to the control group, total bilirubin （TBil） decreased and Alb and PTA increased significantly in treatment group patients after therapy for two weeks . There were statistically significant differences between the two groups （P 〈0.05 ） , but there were no significant statistical differences between the two groups in ALT and AST（ P 〉 0.05 ）. The total hospital days of the treatment group were significantly shorter, and the severe hepatitis incidence and mortality were lower than the control group with statistical difference （ P 〈 0.05）. Conclusion The acute and chronic viral hepatitis patients with heavy tendency which were given short - term shock dexamethasone treatment in the early stage can improve liver function, reduce the incidence of severe hepatitis and mortality, shorten hospital stay.
出处
《临床肝胆病杂志》
CAS
2011年第12期1305-1307,共3页
Journal of Clinical Hepatology
关键词
肝炎
病毒性
人
地塞米松
hepatitis, viral, human
dexamethasone
