摘要
目的探讨全身伽玛刀联合DP方案同步化疗治疗中晚期非小细胞肺癌的近期疗效观察。方法 120例患者均采用全身伽玛刀放疗,总量35～45 Gy,分10～14次完成,每日1次,每周5次;同步行全身化疗,采用DP方案,28天为一周期,每位病人至少完成两周期化疗,伽玛刀治疗结束后3月评价疗效。结果 120例患者近期总有效率(CR+PR)为85%(102/120)。急性放射性肺损伤5.83%(7/120),为1～2度;急性放射性食管损伤的发生率4.17%(5/120),为1～2度;血液毒性主要为白细胞下降,3度发生率为3.33%(4/120),无4度血液毒性发生。随访24月,6、12、24月生存率分别为85.83%(103/120)、54.17%(65/120)、39.17%(47/120)。结论采用全身伽玛刀联合同步化疗治疗中晚期肺癌,具有较高的临床疗效,不良反应较轻,患者可以耐受。
Objective To observe the short-term curative effects of whole body gamma knife combined with concurrent chemotherapy for treatment of advanced non-small cell lung cancer（NSCLC）.Methods All 120 patients were treated with whole body gamma knife combined with concurrent chemotherapy.Radiation was delivered in 10 to 14 fractions with a cumulated marginal dose ranged 35~45 Gy.DP project were given with whole body gamma knife,28d per cycle.At least 2 cycles were delivered.Clinical effects were evaluated 3 months after whole body gamma knife treatment.Results The total efficacy rate was 85.00%（102/120）.Acute radiation induced lung injury was 5.83%（7/120）（Ⅰ~Ⅱ）;acute radiation induced esophagus injury was 4.17%（5/120）（Ⅰ~Ⅱ）;bone marrow toxicity 12.50%（Ⅲ）.In the follow up of 24 months,the survival rates at 6,12 and 24 months were 85.83%（103/120）,54.17%（65/120） and 39.17%（47/120）,respectively.Conclusion Whole body gamma knife combined with concurrent chemotherapy is a feasible,safe,and effective method and could be well tolerated in most patients.It is a good treatment for patients with advanced lung cancer and deserves further investigation.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第12期1431-1433,共3页
Cancer Research on Prevention and Treatment
关键词
全身伽玛刀
化疗
非小细胞肺癌
临床疗效
Whole body gamma knife
Concurrent chemotherapy
Non-small cell lung cancer
Clinical efficacy
