摘要
肿瘤是由肿瘤干细胞异常增殖、分化而形成,常规放化疗仅能消灭增殖期的非致瘤性肿瘤细胞,使肿瘤缩小甚至消失。然而,肿瘤干细胞和普通干细胞一样,对放化疗等方法具有较高的抵抗能力,当治疗停止后,肿瘤干细胞可再次增殖形成肿瘤。目前研究已证实乳腺癌中存在乳腺癌干细胞,并且乳腺癌干细胞在乳腺癌的发生、发展中起着关键作用。乳腺癌干细胞不但介导乳腺癌组织对放化疗的抵抗,还关系到乳腺癌的转移和复发,所以有必要针对乳腺癌干细胞进行深入研究。因此,本文就乳腺癌干细胞的分离鉴定、相关信号通路的调控及其治疗方面的新进展作一综述。
The cancer stem cell hypothesis suggests that tumors originate from the abnormal proliferation and differentiation of cancer stem cells. Conventional therapies, such as radiotherapy and chemotherapy, only kill the non-tumorigenic tumor cells at the pro- liferative phase, resulting in the minifieation or even the disappearance of tumors. However, like normal stem cells, tumor stem cells are highly resistance to radio-chemotherapy, and they may proliferate again to develop the tumor upon cessation of treatment. Cancer stem cells are present in breast cancer and play a key role in the carcinogenesis and progression of breast cancer. They not only mediate resis- tance to chemotherapy and radiotherapy of the breast cancer, but also correlate with metastasis and the recurrence of cancer. Therefore, extensive studies on breast cancer stem cells are needed. The current study summarizes the progress in the isolation and identification of signal pathways and related therapies related to breast cancer stem cells.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2011年第23期1475-1478,共4页
Chinese Journal of Clinical Oncology
关键词
乳腺肿瘤
肿瘤干细胞
研究进展
Breast neopasm
Tumor stem cell
Research progress
