摘要
目的探讨术前新辅助化疗(NAC)对Ⅰb2-Ⅱb期宫颈癌的近期疗效。方法观察组宫颈癌49例,均行病理确诊并采用PT方案(紫杉醇135～175mg/m2+顺铂50mg/m2)静脉化疗2～3个疗程,化疗后15～20d行广泛子宫切除+盆腔淋巴结清扫术。同期手术为对照组。在化疗有效率、术后病理等方面进行分析对比。结果观察组患者化疗有效率77.6%,观察组术后宫旁浸润率、盆腔淋巴结转移率比较差异有显著性(P<0.05);两组手术时间比较差异无显著性,术中出血量观察组明显低于对照组(P<0.05),新辅助化疗有反应者盆腔淋巴结转移及宫旁浸润率较无反应者低(P<0.05)。结论术前新辅助化疗可提高宫颈癌的近期疗效,成为治疗宫颈癌的一种新手段,具有重要临床意义。
Objective To investigate the effect of preoperative Neoadjuvant chemotherapy on Ⅰb2-Ⅱb cervical cancer.Methods From May 2007 to December 2010 in The First Affiliated Hospital of Xiamen University 49 initially treated patients underwent cervical disease and the correct PT program（cisplatin 50mg/m^2＋paclitaxel 135～175mg/m^2） intravenous chemotherapy for 2～3 courses of chemotherapy 15～20 days later radical resection of the uterus and pelvic lymph node dissection were conducted for the observation group.35 cases with surgery at the same period were used as the control group and pathological aspects were compared.Results The overal response rate was 77.6%,parametrial infiltration rate plvic lymph node metastasis was statistically significant（P〈0.05）operative time and blood loss compared with no difference in operative time,observed blood loss was significant lower than the control group which difference was statistically significant（P〈0.05）;Neoadjuvant chemotherapy responders parametrial invasion and pevic lymph node metastasis had lower response rate than those without the difference was significant（P〈0.05）.Conclusion Neoadjuvant chemotherapy is a new and effective method for treatment of stage Ⅰb2-Ⅱb cervical cancer.It shows promising prospect in clinical application.
出处
《中国医药指南》
2011年第34期276-277,共2页
Guide of China Medicine
关键词
新辅助化疗
宫颈肿瘤
手术治疗
Neoadjuvant chemotherapy
Cervical neoplasms
Surgical operation
