摘要
目的：探讨不同剂量补络补管汤对正常小鼠凝血功能的影响，为临床应用此方剂提供实验依据。方法：将３种剂量补络补管汤给正常小鼠灌胃，测定出血时间（ＢＴ）、凝血时间（ＣＴ）、血浆凝血酶原时间（ＰＴ）、纤维蛋白原（Ｆｇ）定量及血小板（ＰＬＴ）计数，与阴性及阳性对照组比较，来阐明此中药方剂对凝血过程的影响途径，并选出最佳服药剂量。结果：３种剂量补络补管汤均能缩短正常小鼠的ＢＴ、ＣＴ、ＰＴ，与阴性对照组比较有显著统计学差异（Ｐ＜０．０５），与阳性对照组比较，无统计学差异（Ｐ＞０．０５）。３种剂量中，以中剂量组效果最佳。３种剂量补络补管汤对Ｆｇ及ＰＬＴ数量无影响，与阴性对照组比较无统计学差异（Ｐ＞０．０５）。结论：补络补管汤对凝血过程的内源性及外源性途径均有影响，最佳服药剂量为中剂量（成人等效剂量）。
Objective: Our aim was to investigate the effects of different doses of Buluo buguantang on the blood coagulation of mice. Methods: We perfused different doses of Buluo buguantang into the stomachs of mice, then measured the bleeding time (BT), coagulation time (CT), prothrombin time (PT), fibrinogen (Fg) and the quantities of platelet (PLT). We compared the results with those of the positive and negative control groups, in order to declare by which way Buluo buguantang had affected the coagulation process and choose the best dose. Results: All the three doses of Buluo buguantang could shorten BT, CT, PT of the normal mice. The group receiving the middle dose showed the best result of the three. The three doses of Buluo buguantang had no effects on Fg and PLT. Conclusion: Buluo buguantang had effects on both intrinsic and extrinsic coagulation processes.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1999年第6期440-442,共3页
Journal of China Medical University
