摘要
卵细胞胞质内单精子注射(ICSI)是一种新型的体外受精技术,有很高的单精受精率,但ICSI技术不能解决所有的受精失败,可能的原因包括卵母细胞质量、受精激活障碍、精子异常以及ICSI技术等问题。IVF超促排卵可能引起卵母细胞内凋亡增加,从而导致受精失败。卵母细胞激活障碍有多种人工辅助的激活方法。ICSI时精子引起的受精失败多是由于精子微小畸形,形态学选择性ICSI是常用的方法。但ICSI后的完全受精失败仍是助孕治疗面临的棘手问题,不能完全避免。
As a new technique for IVF, ICSI has a high rate of monospermy but cannot prevent all fertilization failures, of which the possible causes are poor oocytes or sperm, abnormal oocyte activation, and ICSI technical problems. Controlled ovarian hyperstimulation during IVF could increase the apoptosis of oocytes and subsequently induce fertilization failure. There are several methods for artificial activation in case of oocyte activation failure. Sperm-induced fertilization failure is mostly due to minute malformation of sperm, for which morphologically selective ICSI is generally employed. However, totally failed fertilization after ICSI remains a real challenge.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2011年第12期1131-1134,共4页
National Journal of Andrology
