摘要
目的分析2007—2009年安徽省临床分离痰标本中革兰阴性菌对抗菌药物耐药性变迁情况。方法采用2009年美国CLSI推荐的琼脂对倍稀释法进行抗菌药物敏感实验,计算抗菌药物的耐药率、敏感率和中介率,结果采用SPSS11.5软件进行统计分析。结果 2007年1月至2009年12月从临床送检的痰标本中分离出革兰阴性菌1492株。来自ICU的不动杆菌对亚胺培南及美罗培南的敏感率分别为70.0%和61.3%,其对哌拉西林/三唑巴坦、头孢吡肟、头孢他啶、头孢曲松、庆大霉素、阿米卡星和环丙沙星的耐药率均高于非ICU菌株。来自ICU与非ICU的铜绿假单胞菌对亚胺培南、美罗培南、阿米卡星、头孢他啶的敏感率均在50%以上。来自ICU的铜绿假单胞菌对亚胺培南、美罗培南和庆大霉素的耐药率均高于非ICU菌株。肺炎克雷伯菌对哌拉西林/三唑巴坦、亚胺培南、美罗培南、阿米卡星的耐药率低于30%。大肠埃希菌对哌拉西林/三唑巴坦、亚胺培南、美罗培南、阿米卡星的耐药率在30%以下,对氨苄西林、头孢曲松、氨曲南、庆大霉素、氟喹诺酮类的耐药率大于50%。结论定期进行耐药性监测有助于了解我省细菌耐药性变迁,为临床经验用药提供依据。
Objective To investigate the trend of resistance to antimicrobial agents among clinical isolates isolated from sputum of Gram-negative bacteria in Anhui, from 2007 to 2009. Methods Agar diffusion test was used to analyze the changes of drug susceptibility of Gram-negative bacteria isolated from sputum in Anhui, from 2007 to 2009. The resistant rate, susceptibility rate, and intermediate rate of drugs were calculated according to the criteria recommended by the guidelines of CLSI（2009）. Results A total of 1492 clinical strains isolated from sputum were collected from January 2007 to December 2009. The average susceptibility rates of Acinetobacter collected from ICU to imipenem and meropenem were 70.0% and 61.3%, respectively. The resistance rates of Acinetobacter collected from ICU to piperacillin-tazobactam, cefepime, ceftazidime, ceftriaxone, gentamicin, amikacin, ciprofloxacin were higher than the strains collected from non-ICU. The susceptibility rates of Pseudomonas aeruginosa collected fromICU and non-ICU to piperacillin- tazobactam, imipenem, meropenem, amikacin were higher than 50%. The resistance rates ofK. pneumoniae and E. coli to piperacillin-tazobactam, imipenem, meropenem, amikacin were lower than 30%. The resistance rates to ampicillin, ceftriaxone, aztreonam, fluoroquinolones were higher than 50%. Conclusion The monitoring of drug resistance regularly conduces to learn the changes of antimicrobial resistance of our province and can provide the basis of clinical experience for medication.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第12期948-951,共4页
Chinese Journal of Antibiotics
关键词
不动杆菌
铜绿假单胞菌
肺炎克雷伯菌:大肠埃希菌
药物敏感试验
细菌耐药监测
Acinetobacter
Pseudomonas aeruginosa
Klebsiella pneumoniae
Escherichia coli
Microbialsusceptibility
Bacteral resistance surveillance
