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In vitro production of functional sperm in mice

In vitro production of functional sperm in mice
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摘要 Spermatogenesis refers to the process by which the production and development of the spermatozoa (the mature male gamete of most sexually reproducing species) occurs. It is a complex, stepwise process of sperm development, taking more than a month depending upon the species involving three specific functional phases: spermatogonial proliferation, meiosis and metamorphosis.1 Investigators have been successful in recreating this process in some species of fish; however, this whole process has never been reproduced in vitro in mammals. Spermatogenesis refers to the process by which the production and development of the spermatozoa (the mature male gamete of most sexually reproducing species) occurs. It is a complex, stepwise process of sperm development, taking more than a month depending upon the species involving three specific functional phases: spermatogonial proliferation, meiosis and metamorphosis.1 Investigators have been successful in recreating this process in some species of fish; however, this whole process has never been reproduced in vitro in mammals.
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第6期791-792,共2页 亚洲男性学杂志(英文版)
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参考文献9

  • 1Clermont Y. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol Rev 1972; 52: 198-236. 被引量:1
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  • 9Nayernia K, Nolte J, Michelmann HW, Lee JH, Rathsack K et al. In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Dev Cell 2006; 11: 125-32. 被引量:1

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