摘要
目的观察β受体阻滞剂在治疗心衰患者时对左室收缩功能的影响。方法将安装起博器有心衰症状的左室收缩功能障碍的68例患者,起博频率调整为60次/分并随机均分为两组,治疗组34例在接受ACEI或ARB,氨体舒通治疗稳定的基础上加用β受体阻滞剂治疗;对照组34例接受ACEI或ARB,氨体舒通治疗;疗程为9个月,治疗前后行心脏彩色多普勒检查,测量左室射血分数。结果治疗组与对照组比较,治疗组显著提高平均左室射血分数(P=0.002)。结论在不改变心率的条件下,β受体阻滞剂在治疗心衰患者时可维持左心室收缩功能。
Objective To evaluated the effect on ventricular function in patients with heart failure treated with β-blockers.Methods 68 patients in pacemaker-dependent patients with symptomatic left ventricular（LV） systolic dysfunction seted pacing rate at 60 ppm.34 patients treated by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers,β-blockers,and spironolactone.Other 34 patients treated by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers,and spironolactone.Gated Doppler echocardiography was performed at baseline and after at least 9 months.The primary outcome was change in LVEF,from baseline to follow-up.Results Compared with no β-blockers treatment,34 patients with β-blockers treatment showed an increase in LV ejection fraction（P=0.002 for the difference between groups）.Conclusion β-blockers are effective for treatment of heart failure.
出处
《西部医学》
2011年第12期2347-2348,共2页
Medical Journal of West China
